Design, synthesis, and screening of an RNA optimized fluorinated fragment library

Design, synthesis, and screening of an RNA optimized fluorinated fragment library

Fragment-based screening is an efficient method for early-stage drug discovery. In this study, we aimed to create a fragment library optimized for producing high hit rates against RNA targets. RNA has historically been an underexplored target, but recent research suggests potential for optimizing sm...

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Bibliographic Details
Main Authors: Kasper P. Lundquist, Isabella Romeo, Raffaele B. Puglielli, Maëlle Pestalozzi, Marie L. Gram, Emily S. Hudson, Ofri Levi, Yoav S. Arava, Charlotte H. Gotfredsen, Mads H. Clausen
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:SLAS Discovery
Subjects:
Fragment-based drug discovery
RNA
19F NMR screening
Chemoinformatics
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555225000085
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http://www.sciencedirect.com/science/article/pii/S2472555225000085

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