Ruxolitinib-dependent reduction of seizure load and duration is accompanied by spatial memory improvement in the rat pilocarpine model of temporal lobe epilepsy

Ruxolitinib-dependent reduction of seizure load and duration is accompanied by spatial memory improvement in the rat pilocarpine model of temporal lobe epilepsy

Molecules with optimized pharmacokinetic properties selectively aimed at the inhibition of STAT3 phosphorylation in brain have recently emerged as potential disease modifying therapies for epilepsy. In the current study, pharmacological inhibition of JAK1/2 with the orally available, FDA-approved dr...

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Bibliographic Details
Main Authors: Andrew Carrel, Eleonora Napoli, Kathryn Hixson, Jessica Carlsen, Yasmin Cruz Del Angel, Dana Strode, Nicolas Busquet, Vijay Kumar, Michael F. Wempe, Shelley J. Russek, Amy R. Brooks-Kayal
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Neurotherapeutics
Subjects:
Epilepsy
Hippocampus
Memory
Pilocarpine rat model
Ruxolitinib
Seizure
Online Access:http://www.sciencedirect.com/science/article/pii/S1878747924001934
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