Development of a method for simultaneous analysis of glycosaminoglycan disaccharides and evaluating the quality of chondroitin sulfate and hyaluronic acid in food raw materials

Development of a method for simultaneous analysis of glycosaminoglycan disaccharides and evaluating the quality of chondroitin sulfate and hyaluronic acid in food raw materials

We developed a comprehensive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous analysis of 19 glycosaminoglycan disaccharide components. Although structural similarity among components can hinder MS identification, we optimized the LC conditions to successfully se...

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Bibliographic Details
Main Authors:	Kengo Hirai, Takamasa Ishii, Ayaka Aijima, Nae Yokota, Yasuhisa Miyamoto, Kyohei Higashi, Yusuke Iwasaki, Rie Ito, Nobuaki Higashi, Hiroshi Akiyama
Format:	Article
Language:	English
Published:	Elsevier 2025-01-01
Series:	Food Chemistry: X
Subjects:	Glycosaminoglycan Chondroitin sulfate Hyaluronic acid Unsaturated disaccharide Enzymatic digestion LC-MS/MS
Online Access:	http://www.sciencedirect.com/science/article/pii/S2590157525000860
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