A dominantly acting murine allele of Mcm4 causes chromosomal abnormalities and promotes tumorigenesis.

A dominantly acting murine allele of Mcm4 causes chromosomal abnormalities and promotes tumorigenesis.

Here we report the isolation of a murine model for heritable T cell lymphoblastic leukemia/lymphoma (T-ALL) called Spontaneous dominant leukemia (Sdl). Sdl heterozygous mice develop disease with a short latency and high penetrance, while mice homozygous for the mutation die early during embryonic de...

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Main Authors: Bruce N Bagley, Thomas M Keane, Vilena I Maklakova, Jonathon G Marshall, Rachael A Lester, Michelle M Cancel, Alex R Paulsen, Laura E Bendzick, Raha A Been, Scott C Kogan, Robert T Cormier, Christina Kendziorski, David J Adams, Lara S Collier
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003034&type=printable
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1003034&type=printable

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