A key residue of the extracellular gate provides quality control contributing to ABCG substrate specificity

A key residue of the extracellular gate provides quality control contributing to ABCG substrate specificity

Abstract For G-type ATP-binding cassette (ABC) transporters, a hydrophobic “di-leucine motif” as part of a hydrophobic extracellular gate has been described to separate a large substrate-binding cavity from a smaller upper cavity and proposed to act as a valve controlling drug extrusion. Here, we sh...

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Main Authors: Jian Xia, Alexandra Siffert, Odalys Torres, Francesca Iacobini, Joanna Banasiak, Konrad Pakuła, Jörg Ziegler, Sabine Rosahl, Noel Ferro, Michał Jasiński, Tamás Hegedűs, Markus M. Geisler
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59518-3
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https://doi.org/10.1038/s41467-025-59518-3

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