Two Rare Complications in One Patient: Acquired von Willebrand Syndrome Associated with Intracranial Plasmacytoma
Here, we describe a rare case of acquired von Willebrand syndrome (VWS) associated with intracranial plasmacytoma. The literature includes reports of a few cases of plasmacytoma with central nervous involvement, but none of them with acquired VWS. Diagnosis was made based on a stereotaxic intracereb...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/7609308 |
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| author | H. Auge C. Yguel E. Schmitt B. Frotscher H. Busby-Venner R. Morizot C. Moulin P. Feugier A. Perrot L. Filliatre-Clement |
| author_facet | H. Auge C. Yguel E. Schmitt B. Frotscher H. Busby-Venner R. Morizot C. Moulin P. Feugier A. Perrot L. Filliatre-Clement |
| author_sort | H. Auge |
| collection | DOAJ |
| description | Here, we describe a rare case of acquired von Willebrand syndrome (VWS) associated with intracranial plasmacytoma. The literature includes reports of a few cases of plasmacytoma with central nervous involvement, but none of them with acquired VWS. Diagnosis was made based on a stereotaxic intracerebral biopsy. During this biopsy, a ventriculoperitoneal shunt was established, which was complicated with abnormal bleeding. Subsequent hemostasis assessment related to hemopathy revealed acquired von Willebrand disease. The patient received induction therapy with bortezomib, thalidomide, and dexamethasone (VTD), followed by high-dose melphalan chemotherapy and autologous stem cell transplantation, and then VTD consolidation, and finally maintenance with lenalidomide. Our patient currently remains in very good partial response without neurological symptoms after 4 months of maintenance. The patient is free of progression 14 months after their original presentation. |
| format | Article |
| id | doaj-art-39793381a795495e953642bc5aa5a2b0 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-39793381a795495e953642bc5aa5a2b02025-02-03T05:50:24ZengWileyCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/76093087609308Two Rare Complications in One Patient: Acquired von Willebrand Syndrome Associated with Intracranial PlasmacytomaH. Auge0C. Yguel1E. Schmitt2B. Frotscher3H. Busby-Venner4R. Morizot5C. Moulin6P. Feugier7A. Perrot8L. Filliatre-Clement9Hematology Department, University Hospital of Nancy, 5 Rue du Morvan, 54500 Vandoeuvre les Nancy, FranceHistopathology Department, University Hospital of Nancy, 5 Rue du Morvan, 54500 Vandoeuvre les Nancy, FranceNeuroradiology Department, University Hospital of Nancy, 29 Avenue du Maréchal de Lattre de Tassigny, 54035 Nancy, FranceHemostasis Department, University Hospital of Nancy, 5 Rue du Morvan, 54500 Vandoeuvre les Nancy, FranceHistopathology Department, University Hospital of Nancy, 5 Rue du Morvan, 54500 Vandoeuvre les Nancy, FranceHematology Department, University Hospital of Nancy, 5 Rue du Morvan, 54500 Vandoeuvre les Nancy, FranceHematology Department, University Hospital of Nancy, 5 Rue du Morvan, 54500 Vandoeuvre les Nancy, FranceHematology Department, University Hospital of Nancy, 5 Rue du Morvan, 54500 Vandoeuvre les Nancy, FranceHematology Department, University Hospital of Nancy, 5 Rue du Morvan, 54500 Vandoeuvre les Nancy, FranceHematology Department, University Hospital of Nancy, 5 Rue du Morvan, 54500 Vandoeuvre les Nancy, FranceHere, we describe a rare case of acquired von Willebrand syndrome (VWS) associated with intracranial plasmacytoma. The literature includes reports of a few cases of plasmacytoma with central nervous involvement, but none of them with acquired VWS. Diagnosis was made based on a stereotaxic intracerebral biopsy. During this biopsy, a ventriculoperitoneal shunt was established, which was complicated with abnormal bleeding. Subsequent hemostasis assessment related to hemopathy revealed acquired von Willebrand disease. The patient received induction therapy with bortezomib, thalidomide, and dexamethasone (VTD), followed by high-dose melphalan chemotherapy and autologous stem cell transplantation, and then VTD consolidation, and finally maintenance with lenalidomide. Our patient currently remains in very good partial response without neurological symptoms after 4 months of maintenance. The patient is free of progression 14 months after their original presentation.http://dx.doi.org/10.1155/2019/7609308 |
| spellingShingle | H. Auge C. Yguel E. Schmitt B. Frotscher H. Busby-Venner R. Morizot C. Moulin P. Feugier A. Perrot L. Filliatre-Clement Two Rare Complications in One Patient: Acquired von Willebrand Syndrome Associated with Intracranial Plasmacytoma Case Reports in Hematology |
| title | Two Rare Complications in One Patient: Acquired von Willebrand Syndrome Associated with Intracranial Plasmacytoma |
| title_full | Two Rare Complications in One Patient: Acquired von Willebrand Syndrome Associated with Intracranial Plasmacytoma |
| title_fullStr | Two Rare Complications in One Patient: Acquired von Willebrand Syndrome Associated with Intracranial Plasmacytoma |
| title_full_unstemmed | Two Rare Complications in One Patient: Acquired von Willebrand Syndrome Associated with Intracranial Plasmacytoma |
| title_short | Two Rare Complications in One Patient: Acquired von Willebrand Syndrome Associated with Intracranial Plasmacytoma |
| title_sort | two rare complications in one patient acquired von willebrand syndrome associated with intracranial plasmacytoma |
| url | http://dx.doi.org/10.1155/2019/7609308 |
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