Resolution of Refractory Status Epilepticus With Ketamine Without Intubation in a Patient With Stroke-Like Migraine Attacks After Radiation Therapy (SMART) Syndrome

Stroke-like migraine attacks after radiation therapy (SMART) syndrome is an infrequently reported complication arising years after radiation therapy that manifests as a reversible syndrome marked by migraine-like headaches, focal neurologic signs, and/or seizures. Refractory status epilepticus (RSE)...

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Main Authors: Kyle N. Kaneko, Pablo Read, John M. Eaton, Yoshie Umemura, Justin L. Hoskin
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Case Reports in Neurological Medicine
Online Access:http://dx.doi.org/10.1155/crnm/3203322
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author Kyle N. Kaneko
Pablo Read
John M. Eaton
Yoshie Umemura
Justin L. Hoskin
author_facet Kyle N. Kaneko
Pablo Read
John M. Eaton
Yoshie Umemura
Justin L. Hoskin
author_sort Kyle N. Kaneko
collection DOAJ
description Stroke-like migraine attacks after radiation therapy (SMART) syndrome is an infrequently reported complication arising years after radiation therapy that manifests as a reversible syndrome marked by migraine-like headaches, focal neurologic signs, and/or seizures. Refractory status epilepticus (RSE) associated with SMART syndrome is rare and can be challenging to treat. Valproic acid has been reported to improve seizures in RSE in SMART syndrome in a few case reports and may be ideal for SMART syndrome, given its use in the treatment of migraines and seizures. Ketamine has been used in RSE and a few instances in SMART syndrome. Here, we present a case of refractory focal status epilepticus in a patient with SMART syndrome who was treated with ketamine, which resolved seizures without the need for intubation.
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institution Kabale University
issn 2090-6676
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publishDate 2025-01-01
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series Case Reports in Neurological Medicine
spelling doaj-art-395799d01cac44c6b2238a1c5d13dacb2025-02-12T05:00:04ZengWileyCase Reports in Neurological Medicine2090-66762025-01-01202510.1155/crnm/3203322Resolution of Refractory Status Epilepticus With Ketamine Without Intubation in a Patient With Stroke-Like Migraine Attacks After Radiation Therapy (SMART) SyndromeKyle N. Kaneko0Pablo Read1John M. Eaton2Yoshie Umemura3Justin L. Hoskin4Department of NeurologyDepartment of NeurologyDepartment of NeurologyDepartment of NeurologyDepartment of NeurologyStroke-like migraine attacks after radiation therapy (SMART) syndrome is an infrequently reported complication arising years after radiation therapy that manifests as a reversible syndrome marked by migraine-like headaches, focal neurologic signs, and/or seizures. Refractory status epilepticus (RSE) associated with SMART syndrome is rare and can be challenging to treat. Valproic acid has been reported to improve seizures in RSE in SMART syndrome in a few case reports and may be ideal for SMART syndrome, given its use in the treatment of migraines and seizures. Ketamine has been used in RSE and a few instances in SMART syndrome. Here, we present a case of refractory focal status epilepticus in a patient with SMART syndrome who was treated with ketamine, which resolved seizures without the need for intubation.http://dx.doi.org/10.1155/crnm/3203322
spellingShingle Kyle N. Kaneko
Pablo Read
John M. Eaton
Yoshie Umemura
Justin L. Hoskin
Resolution of Refractory Status Epilepticus With Ketamine Without Intubation in a Patient With Stroke-Like Migraine Attacks After Radiation Therapy (SMART) Syndrome
Case Reports in Neurological Medicine
title Resolution of Refractory Status Epilepticus With Ketamine Without Intubation in a Patient With Stroke-Like Migraine Attacks After Radiation Therapy (SMART) Syndrome
title_full Resolution of Refractory Status Epilepticus With Ketamine Without Intubation in a Patient With Stroke-Like Migraine Attacks After Radiation Therapy (SMART) Syndrome
title_fullStr Resolution of Refractory Status Epilepticus With Ketamine Without Intubation in a Patient With Stroke-Like Migraine Attacks After Radiation Therapy (SMART) Syndrome
title_full_unstemmed Resolution of Refractory Status Epilepticus With Ketamine Without Intubation in a Patient With Stroke-Like Migraine Attacks After Radiation Therapy (SMART) Syndrome
title_short Resolution of Refractory Status Epilepticus With Ketamine Without Intubation in a Patient With Stroke-Like Migraine Attacks After Radiation Therapy (SMART) Syndrome
title_sort resolution of refractory status epilepticus with ketamine without intubation in a patient with stroke like migraine attacks after radiation therapy smart syndrome
url http://dx.doi.org/10.1155/crnm/3203322
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