Scalable Production of Recombinant Adeno-Associated Virus Vectors Expressing Soluble Viral Receptors for Broad-Spectrum Inhibition of Porcine Reproductive and Respiratory Syndrome Virus Type 2

Scalable Production of Recombinant Adeno-Associated Virus Vectors Expressing Soluble Viral Receptors for Broad-Spectrum Inhibition of Porcine Reproductive and Respiratory Syndrome Virus Type 2

Porcine reproductive and respiratory syndrome virus (PRRSV) continues to be a major threat to the global swine industry, causing significant economic losses. To address this, we developed a scalable recombinant adeno-associated virus (rAAV)-based strategy for the delivery of soluble viral receptors...

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Bibliographic Details
Main Authors: Xiaoming Liu, Nuo Xu, Xiaoli Song, Linlin Zhuang, Qiuping Shen, Huaichang Sun
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Veterinary Sciences
Subjects:
PRRSV
soluble viral receptor fusions
adeno-associated virus vector
insect cell bioreactor
broad-spectrum antiviral activity
Online Access:https://www.mdpi.com/2306-7381/12/4/366
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