Relationship of serum total cholesterol and triglyceride with risk of mortality in maintenance hemodialysis patients: a multicenter prospective cohort study
Objective The relationship between serum total cholesterol (TC) and triglyceride (TG) levels and mortality in maintenance hemodialysis (MHD) patients remains inconsistent. We aimed to explore the individual and combined association of TC and TG levels with the risk of mortality in Chinese MHD patien...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2334912 |
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| author | Yan Huang Qiuxia Zhong Junzhi Chen Xianhui Qin Yaya Yang Yanhuan He Zizhen Lin Yumin Li Shenglin Yang Yongxin Lu Yanhong Zhao Yaozhong Kong Qijun Wan Qi Wang Sheng Huang Yan Liu Aiqun Liu Fanna Liu Fanfan Hou Min Liang |
| author_facet | Yan Huang Qiuxia Zhong Junzhi Chen Xianhui Qin Yaya Yang Yanhuan He Zizhen Lin Yumin Li Shenglin Yang Yongxin Lu Yanhong Zhao Yaozhong Kong Qijun Wan Qi Wang Sheng Huang Yan Liu Aiqun Liu Fanna Liu Fanfan Hou Min Liang |
| author_sort | Yan Huang |
| collection | DOAJ |
| description | Objective The relationship between serum total cholesterol (TC) and triglyceride (TG) levels and mortality in maintenance hemodialysis (MHD) patients remains inconsistent. We aimed to explore the individual and combined association of TC and TG levels with the risk of mortality in Chinese MHD patients.Methods 1036 MHD patients were enrolled in this multicenter, prospective cohort study. The serum levels of total cholesterol and triglycerides were measured at baseline. The primary outcome was all-cause mortality and secondary outcome was cardiovascular disease (CVD) mortality.Results During a median follow-up duration of 4.4 years (IQR= 2.0–7.9 years), 549 (53.0%) patients died, and 297 (28.7%) deaths were attributed to CVD. Compared with patients with TC levels in the first three quartiles (<182.5 mg/dL), a significantly higher risk of all-cause mortality was found in participants with TC in the fourth quartile (hazard ratio [HR], 1.43; 95% confidence interval [CI], 1.17–1.76). However, a significantly lower risk of all-cause mortality was observed in participants with TG in the fourth quartile (≥193.9 mg/dL) (HR, 0.78; 95%CI: 0.63–0.98), compared with participants with TG in the first three quartiles. Similar trends were observed in CVD mortality. When analyzed jointly, patients with lower TC (<182.5 mg/dL) and higher TG (≥193.9 mg/dL) levels had the lowest risk of all-cause mortality and CVD mortality.Conclusions: In MHD patients in southern China, higher TC levels were associated with higher risk of mortality, while higher TG levels were related to lower risk of mortality. Patients with lower TC and higher TG levels had the best survival prognosis. |
| format | Article |
| id | doaj-art-38ee1e933d124f23a8900797b9e97f60 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-38ee1e933d124f23a8900797b9e97f602025-01-23T04:17:47ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2334912Relationship of serum total cholesterol and triglyceride with risk of mortality in maintenance hemodialysis patients: a multicenter prospective cohort studyYan Huang0Qiuxia Zhong1Junzhi Chen2Xianhui Qin3Yaya Yang4Yanhuan He5Zizhen Lin6Yumin Li7Shenglin Yang8Yongxin Lu9Yanhong Zhao10Yaozhong Kong11Qijun Wan12Qi Wang13Sheng Huang14Yan Liu15Aiqun Liu16Fanna Liu17Fanfan Hou18Min Liang19Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDivision of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDivision of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDivision of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDivision of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDivision of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDivision of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDivision of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDivision of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaPeople’s Hospital of Yuxi City, Yuxi, ChinaPeople’s Hospital of Yuxi City, Yuxi, ChinaThe First People’s Hospital of Foshan, Foshan, ChinaThe Second People’s Hospital of Shenzhen, Shenzhen, ChinaHuadu District People’s Hospital of Guangzhou, Guangzhou, ChinaNanhai District People’s Hospital of Foshan, Foshan, ChinaGuangzhou Red Cross Hospital, Guangzhou, ChinaThe Third Affiliated Hospital of Southern Medical University, Guangzhou, ChinaGuangzhou Overseas Chinese Hospital, Guangzhou, ChinaDivision of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaDivision of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, ChinaObjective The relationship between serum total cholesterol (TC) and triglyceride (TG) levels and mortality in maintenance hemodialysis (MHD) patients remains inconsistent. We aimed to explore the individual and combined association of TC and TG levels with the risk of mortality in Chinese MHD patients.Methods 1036 MHD patients were enrolled in this multicenter, prospective cohort study. The serum levels of total cholesterol and triglycerides were measured at baseline. The primary outcome was all-cause mortality and secondary outcome was cardiovascular disease (CVD) mortality.Results During a median follow-up duration of 4.4 years (IQR= 2.0–7.9 years), 549 (53.0%) patients died, and 297 (28.7%) deaths were attributed to CVD. Compared with patients with TC levels in the first three quartiles (<182.5 mg/dL), a significantly higher risk of all-cause mortality was found in participants with TC in the fourth quartile (hazard ratio [HR], 1.43; 95% confidence interval [CI], 1.17–1.76). However, a significantly lower risk of all-cause mortality was observed in participants with TG in the fourth quartile (≥193.9 mg/dL) (HR, 0.78; 95%CI: 0.63–0.98), compared with participants with TG in the first three quartiles. Similar trends were observed in CVD mortality. When analyzed jointly, patients with lower TC (<182.5 mg/dL) and higher TG (≥193.9 mg/dL) levels had the lowest risk of all-cause mortality and CVD mortality.Conclusions: In MHD patients in southern China, higher TC levels were associated with higher risk of mortality, while higher TG levels were related to lower risk of mortality. Patients with lower TC and higher TG levels had the best survival prognosis.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2334912Serum total cholesterolserum triglyceridemaintenance hemodialysismortalitycardiovascular mortality |
| spellingShingle | Yan Huang Qiuxia Zhong Junzhi Chen Xianhui Qin Yaya Yang Yanhuan He Zizhen Lin Yumin Li Shenglin Yang Yongxin Lu Yanhong Zhao Yaozhong Kong Qijun Wan Qi Wang Sheng Huang Yan Liu Aiqun Liu Fanna Liu Fanfan Hou Min Liang Relationship of serum total cholesterol and triglyceride with risk of mortality in maintenance hemodialysis patients: a multicenter prospective cohort study Renal Failure Serum total cholesterol serum triglyceride maintenance hemodialysis mortality cardiovascular mortality |
| title | Relationship of serum total cholesterol and triglyceride with risk of mortality in maintenance hemodialysis patients: a multicenter prospective cohort study |
| title_full | Relationship of serum total cholesterol and triglyceride with risk of mortality in maintenance hemodialysis patients: a multicenter prospective cohort study |
| title_fullStr | Relationship of serum total cholesterol and triglyceride with risk of mortality in maintenance hemodialysis patients: a multicenter prospective cohort study |
| title_full_unstemmed | Relationship of serum total cholesterol and triglyceride with risk of mortality in maintenance hemodialysis patients: a multicenter prospective cohort study |
| title_short | Relationship of serum total cholesterol and triglyceride with risk of mortality in maintenance hemodialysis patients: a multicenter prospective cohort study |
| title_sort | relationship of serum total cholesterol and triglyceride with risk of mortality in maintenance hemodialysis patients a multicenter prospective cohort study |
| topic | Serum total cholesterol serum triglyceride maintenance hemodialysis mortality cardiovascular mortality |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2334912 |
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