Identification of key biomarkers of the glomerulus in focal segmental glomerulosclerosis and their relationship with immune cell infiltration based on WGCNA and the LASSO algorithm

Identification of key biomarkers of the glomerulus in focal segmental glomerulosclerosis and their relationship with immune cell infiltration based on WGCNA and the LASSO algorithm

Objective The aim of our study was to identify key biomarkers of glomeruli in focal glomerulosclerosis (FSGS) and analyze their relationship with the infiltration of immune cells.Methods The expression profiles (GSE108109 and GSE200828) were obtained from the GEO database. The differentially express...

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Bibliographic Details
Main Authors: Yun Xia Zhang, Juan Lv, Jun Yuan Bai, XiaoWei Pu, En Lai Dai
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Renal Failure
Subjects:
Focal segmental glomerulosclerosis
weighted gene coexpression network analysis
least absolute shrinkage and selection operator
immune cell infiltration
TGFB1
NOTCH1
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2023.2202264
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https://www.tandfonline.com/doi/10.1080/0886022X.2023.2202264

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