The proteome of circulating extracellular vesicles and their functional effect on platelets vary with the isolation method

The proteome of circulating extracellular vesicles and their functional effect on platelets vary with the isolation method

Abstract Extracellular vesicles (EVs) play a crucial role in cell-to-cell communication and serve as a source of biomarkers in several pathologies. In this study, we aimed to characterize plasma-derived EVs isolated by ultracentrifugation (UC) or size exclusion chromatography (SEC) to define the bes...

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Bibliographic Details
Main Authors: Eva M. Fernández-Sáez, Susana B. Bravo, Carmen Pena, Ángel García
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Extracellular vesicles
Ultracentrifugation
Size exclusion chromatography
Platelets
Proteomics
Online Access:https://doi.org/10.1038/s41598-025-05374-6
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https://doi.org/10.1038/s41598-025-05374-6

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