Doubling of Decipher Biopsy Genomic Score Is Related to Disease Reclassification on Subsequent Surveillance Biopsy but Not Adverse Features on Radical Prostatectomy
The utility of serial Decipher biopsy scores in a true active surveillance population is still unknown. In a man on active surveillance for low-risk prostate cancer, a doubling of the Decipher biopsy score within genomic low-risk category from first to the second biopsy related to biopsy reclassific...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Urology |
| Online Access: | http://dx.doi.org/10.1155/2021/2687416 |
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| author | Kamyar Ghabili Nathan Paulson Jamil S. Syed Cayce B. Nawaf Ghazal Khajir Darryl T. Martin John Onofrey Michael S. Leapman Angelique Levi Jeffrey C. Weinreb Peter A. Humphrey Preston C. Sprenkle |
| author_facet | Kamyar Ghabili Nathan Paulson Jamil S. Syed Cayce B. Nawaf Ghazal Khajir Darryl T. Martin John Onofrey Michael S. Leapman Angelique Levi Jeffrey C. Weinreb Peter A. Humphrey Preston C. Sprenkle |
| author_sort | Kamyar Ghabili |
| collection | DOAJ |
| description | The utility of serial Decipher biopsy scores in a true active surveillance population is still unknown. In a man on active surveillance for low-risk prostate cancer, a doubling of the Decipher biopsy score within genomic low-risk category from first to the second biopsy related to biopsy reclassification to Gleason grade group 4 on the third biopsy. However, the final pathology at radical prostatectomy showed Gleason grade group 2 with an organ-confined disease. This case suggests that the genomic risk category of Decipher biopsy scores during active surveillance may be more informative than either the interval genomic score change or the biopsy Gleason grade group. |
| format | Article |
| id | doaj-art-38ad0f8f05204969b9ba9610e00aa9cb |
| institution | Kabale University |
| issn | 2090-696X 2090-6978 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Urology |
| spelling | doaj-art-38ad0f8f05204969b9ba9610e00aa9cb2025-02-03T00:58:46ZengWileyCase Reports in Urology2090-696X2090-69782021-01-01202110.1155/2021/26874162687416Doubling of Decipher Biopsy Genomic Score Is Related to Disease Reclassification on Subsequent Surveillance Biopsy but Not Adverse Features on Radical ProstatectomyKamyar Ghabili0Nathan Paulson1Jamil S. Syed2Cayce B. Nawaf3Ghazal Khajir4Darryl T. Martin5John Onofrey6Michael S. Leapman7Angelique Levi8Jeffrey C. Weinreb9Peter A. Humphrey10Preston C. Sprenkle11Department of Urology, Yale University School of Medicine, New Haven, CT, USADepartment of Pathology, Yale University School of Medicine, New Haven, CT, USADepartment of Urology, Yale University School of Medicine, New Haven, CT, USADepartment of Urology, Yale University School of Medicine, New Haven, CT, USADepartment of Urology, Yale University School of Medicine, New Haven, CT, USADepartment of Urology, Yale University School of Medicine, New Haven, CT, USADepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USADepartment of Urology, Yale University School of Medicine, New Haven, CT, USADepartment of Pathology, Yale University School of Medicine, New Haven, CT, USADepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USADepartment of Pathology, Yale University School of Medicine, New Haven, CT, USADepartment of Urology, Yale University School of Medicine, New Haven, CT, USAThe utility of serial Decipher biopsy scores in a true active surveillance population is still unknown. In a man on active surveillance for low-risk prostate cancer, a doubling of the Decipher biopsy score within genomic low-risk category from first to the second biopsy related to biopsy reclassification to Gleason grade group 4 on the third biopsy. However, the final pathology at radical prostatectomy showed Gleason grade group 2 with an organ-confined disease. This case suggests that the genomic risk category of Decipher biopsy scores during active surveillance may be more informative than either the interval genomic score change or the biopsy Gleason grade group.http://dx.doi.org/10.1155/2021/2687416 |
| spellingShingle | Kamyar Ghabili Nathan Paulson Jamil S. Syed Cayce B. Nawaf Ghazal Khajir Darryl T. Martin John Onofrey Michael S. Leapman Angelique Levi Jeffrey C. Weinreb Peter A. Humphrey Preston C. Sprenkle Doubling of Decipher Biopsy Genomic Score Is Related to Disease Reclassification on Subsequent Surveillance Biopsy but Not Adverse Features on Radical Prostatectomy Case Reports in Urology |
| title | Doubling of Decipher Biopsy Genomic Score Is Related to Disease Reclassification on Subsequent Surveillance Biopsy but Not Adverse Features on Radical Prostatectomy |
| title_full | Doubling of Decipher Biopsy Genomic Score Is Related to Disease Reclassification on Subsequent Surveillance Biopsy but Not Adverse Features on Radical Prostatectomy |
| title_fullStr | Doubling of Decipher Biopsy Genomic Score Is Related to Disease Reclassification on Subsequent Surveillance Biopsy but Not Adverse Features on Radical Prostatectomy |
| title_full_unstemmed | Doubling of Decipher Biopsy Genomic Score Is Related to Disease Reclassification on Subsequent Surveillance Biopsy but Not Adverse Features on Radical Prostatectomy |
| title_short | Doubling of Decipher Biopsy Genomic Score Is Related to Disease Reclassification on Subsequent Surveillance Biopsy but Not Adverse Features on Radical Prostatectomy |
| title_sort | doubling of decipher biopsy genomic score is related to disease reclassification on subsequent surveillance biopsy but not adverse features on radical prostatectomy |
| url | http://dx.doi.org/10.1155/2021/2687416 |
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