N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth
Highly penetrant mutations leading to schizophrenia are enriched for genes coding for N-methyl-D-aspartate receptor signaling complex (NMDAR-SC), implicating plasticity defects in the disease’s pathogenesis. The importance of plasticity in neurodevelopment implies a role for therapies that target th...
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/4209831 |
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| author | Joseph Gonzalez-Heydrich Michelle Bosquet Enlow Eugene D’Angelo Larry J. Seidman Sarah Gumlak April Kim Kristen A. Woodberry Ashley Rober Sahil Tembulkar Kyle O’Donnell Hesham M. Hamoda Kara Kimball Alexander Rotenberg Lindsay M. Oberman Alvaro Pascual-Leone Matcheri S. Keshavan Frank H. Duffy |
| author_facet | Joseph Gonzalez-Heydrich Michelle Bosquet Enlow Eugene D’Angelo Larry J. Seidman Sarah Gumlak April Kim Kristen A. Woodberry Ashley Rober Sahil Tembulkar Kyle O’Donnell Hesham M. Hamoda Kara Kimball Alexander Rotenberg Lindsay M. Oberman Alvaro Pascual-Leone Matcheri S. Keshavan Frank H. Duffy |
| author_sort | Joseph Gonzalez-Heydrich |
| collection | DOAJ |
| description | Highly penetrant mutations leading to schizophrenia are enriched for genes coding for N-methyl-D-aspartate receptor signaling complex (NMDAR-SC), implicating plasticity defects in the disease’s pathogenesis. The importance of plasticity in neurodevelopment implies a role for therapies that target these mechanisms in early life to prevent schizophrenia. Testing such therapies requires noninvasive methods that can assess engagement of target mechanisms. The auditory N100 is an obligatory cortical response whose amplitude decreases with tone repetition. This adaptation may index the health of plasticity mechanisms required for normal development. We exposed participants aged 5 to 17 years with psychosis n=22, at clinical high risk (CHR) for psychosis n=29, and healthy controls n=17 to an auditory tone repeated 450 times and measured N100 adaptation (mean amplitude during first 150 tones − mean amplitude during last 150 tones). N100 adaptation was reduced in CHR and psychosis, particularly among participants <13 years old. Initial N100 blunting partially accounted for differences. Decreased change in the N100 amplitude with tone repetition may be a useful marker of defects in neuroplastic mechanisms measurable early in life. |
| format | Article |
| id | doaj-art-38ac93c4efaa43dba90e8e03e44ec71e |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-38ac93c4efaa43dba90e8e03e44ec71e2025-02-03T07:25:36ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/42098314209831N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic YouthJoseph Gonzalez-Heydrich0Michelle Bosquet Enlow1Eugene D’Angelo2Larry J. Seidman3Sarah Gumlak4April Kim5Kristen A. Woodberry6Ashley Rober7Sahil Tembulkar8Kyle O’Donnell9Hesham M. Hamoda10Kara Kimball11Alexander Rotenberg12Lindsay M. Oberman13Alvaro Pascual-Leone14Matcheri S. Keshavan15Frank H. Duffy16Boston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115, USABoston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115, USABoston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115, USADepartment of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, MA 02215, USABoston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115, USABoston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115, USADepartment of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, MA 02215, USABoston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115, USABoston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115, USABoston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115, USABoston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115, USABoston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115, USABoston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115, USANeuroplasticity and Autism Spectrum Disorder Program and Department of Psychiatry and Human Behavior, E.P. Bradley Hospital and Warren Alpert Medical School, Brown University, 1011 Veterans Memorial Parkway, East Providence, RI 02915, USADepartment of Psychiatry, Commonwealth Research Center, Beth Israel Deaconess Medical Center, 75 Fenwood Road, Boston, MA 02115, USADepartment of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, MA 02215, USABoston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115, USAHighly penetrant mutations leading to schizophrenia are enriched for genes coding for N-methyl-D-aspartate receptor signaling complex (NMDAR-SC), implicating plasticity defects in the disease’s pathogenesis. The importance of plasticity in neurodevelopment implies a role for therapies that target these mechanisms in early life to prevent schizophrenia. Testing such therapies requires noninvasive methods that can assess engagement of target mechanisms. The auditory N100 is an obligatory cortical response whose amplitude decreases with tone repetition. This adaptation may index the health of plasticity mechanisms required for normal development. We exposed participants aged 5 to 17 years with psychosis n=22, at clinical high risk (CHR) for psychosis n=29, and healthy controls n=17 to an auditory tone repeated 450 times and measured N100 adaptation (mean amplitude during first 150 tones − mean amplitude during last 150 tones). N100 adaptation was reduced in CHR and psychosis, particularly among participants <13 years old. Initial N100 blunting partially accounted for differences. Decreased change in the N100 amplitude with tone repetition may be a useful marker of defects in neuroplastic mechanisms measurable early in life.http://dx.doi.org/10.1155/2016/4209831 |
| spellingShingle | Joseph Gonzalez-Heydrich Michelle Bosquet Enlow Eugene D’Angelo Larry J. Seidman Sarah Gumlak April Kim Kristen A. Woodberry Ashley Rober Sahil Tembulkar Kyle O’Donnell Hesham M. Hamoda Kara Kimball Alexander Rotenberg Lindsay M. Oberman Alvaro Pascual-Leone Matcheri S. Keshavan Frank H. Duffy N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth Neural Plasticity |
| title | N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth |
| title_full | N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth |
| title_fullStr | N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth |
| title_full_unstemmed | N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth |
| title_short | N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth |
| title_sort | n100 repetition suppression indexes neuroplastic defects in clinical high risk and psychotic youth |
| url | http://dx.doi.org/10.1155/2016/4209831 |
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