Thioredoxin-interacting protein (TXNIP) inhibition promotes retinal ganglion cell survival and facilitates M1-like microglial transformation via the PI3K/Akt pathway in glaucoma

Thioredoxin-interacting protein (TXNIP) inhibition promotes retinal ganglion cell survival and facilitates M1-like microglial transformation via the PI3K/Akt pathway in glaucoma

Abstract Background Glaucoma is a group of heterogeneous neurodegenerative diseases with abnormal energy metabolism and imbalanced neuroinflammation in the retina. Thioredoxin-interacting protein (TXNIP) is involved in glucose and lipid metabolism, and associated with oxidative stress and inflammati...

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Bibliographic Details
Main Authors: Junjue Chen, Huimin Zhong, Bingqiao Shen, Huan Yu, Yang Zhang, Ruiqi Han, Ping Huang, Shouyue Huang, Yisheng Zhong
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Molecular Medicine
Subjects:
TXNIP
Microglia
Experimental glaucoma
PI3K/AKT
Neuroinflammation
Energy metabolism
Online Access:https://doi.org/10.1186/s10020-024-01058-5
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https://doi.org/10.1186/s10020-024-01058-5

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