Haploidentical Stem Cell Transplantation: A Gateway to Infrequent Availability of HLA-Matched Related Donors
Haploidentical stem cell transplantation provides a plausible alternative for the patients when a fully matched donor is unavailable. Historically, the decision of considering haploidentical transplant has remained elusive; however, with the recent advances, the consideration of haploidentical graft...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/2573657 |
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| author | Hafiz Muhammad Aslam Shumaila Muhammad Iqbal Hira Shaikh Faizan A. Faizee Ambreen A. Merchant Marwan Shaheen Shahrukh K. Hashmi |
| author_facet | Hafiz Muhammad Aslam Shumaila Muhammad Iqbal Hira Shaikh Faizan A. Faizee Ambreen A. Merchant Marwan Shaheen Shahrukh K. Hashmi |
| author_sort | Hafiz Muhammad Aslam |
| collection | DOAJ |
| description | Haploidentical stem cell transplantation provides a plausible alternative for the patients when a fully matched donor is unavailable. Historically, the decision of considering haploidentical transplant has remained elusive; however, with the recent advances, the consideration of haploidentical grafts as a treatment option has become more apparent for both allografting for diseases and engraftment failure. We are reporting here an anecdotal case of a successful haploidentical engraftment in a patient with the prior graft failure of an HLA-matched related donor. Since the patient was severely alloimmunized, desensitization protocol was utilized before the haploidentical transplant, and the patient after 8 months of her second allogeneic transplantation is doing great with successful engraftment, no relapse, and no graft-versus-host disease (GVHD). Numerous reports pertinent to haploidentical graft have shown favorable outcomes in the graft placement, a decline in the rate of GVHD, and an improvement in the morbidity and mortality in affected individuals. Based on the current reports, haploidentical transplantation might be more feasible and has meaningful implications in the situations where matched donors are infrequent. |
| format | Article |
| id | doaj-art-38a0066cf8ac4bbcb610f76dcde06917 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-38a0066cf8ac4bbcb610f76dcde069172025-02-03T05:43:44ZengWileyCase Reports in Medicine1687-96271687-96352018-01-01201810.1155/2018/25736572573657Haploidentical Stem Cell Transplantation: A Gateway to Infrequent Availability of HLA-Matched Related DonorsHafiz Muhammad Aslam0Shumaila Muhammad Iqbal1Hira Shaikh2Faizan A. Faizee3Ambreen A. Merchant4Marwan Shaheen5Shahrukh K. Hashmi6Department of Internal Medicine, Seton Hall University (St Francis) Program, Trenton, USADepartment of Internal Medicine, University at Buffalo (Catholic Health System-Sisters of Charity) Program, Buffalo, USADepartment of Internal Medicine, Allegheny Health Network, Pennsylvania, USADow Medical College, Dow University of Health Sciences, Karachi, PakistanDow Medical College, Dow University of Health Sciences, Karachi, PakistanKing Faisal University Hospital and Research Center, Riyadh, Saudi ArabiaDepartment of Medicine, Division of Hematology, Mayo Clinic, Rochester, MN 55905, USAHaploidentical stem cell transplantation provides a plausible alternative for the patients when a fully matched donor is unavailable. Historically, the decision of considering haploidentical transplant has remained elusive; however, with the recent advances, the consideration of haploidentical grafts as a treatment option has become more apparent for both allografting for diseases and engraftment failure. We are reporting here an anecdotal case of a successful haploidentical engraftment in a patient with the prior graft failure of an HLA-matched related donor. Since the patient was severely alloimmunized, desensitization protocol was utilized before the haploidentical transplant, and the patient after 8 months of her second allogeneic transplantation is doing great with successful engraftment, no relapse, and no graft-versus-host disease (GVHD). Numerous reports pertinent to haploidentical graft have shown favorable outcomes in the graft placement, a decline in the rate of GVHD, and an improvement in the morbidity and mortality in affected individuals. Based on the current reports, haploidentical transplantation might be more feasible and has meaningful implications in the situations where matched donors are infrequent.http://dx.doi.org/10.1155/2018/2573657 |
| spellingShingle | Hafiz Muhammad Aslam Shumaila Muhammad Iqbal Hira Shaikh Faizan A. Faizee Ambreen A. Merchant Marwan Shaheen Shahrukh K. Hashmi Haploidentical Stem Cell Transplantation: A Gateway to Infrequent Availability of HLA-Matched Related Donors Case Reports in Medicine |
| title | Haploidentical Stem Cell Transplantation: A Gateway to Infrequent Availability of HLA-Matched Related Donors |
| title_full | Haploidentical Stem Cell Transplantation: A Gateway to Infrequent Availability of HLA-Matched Related Donors |
| title_fullStr | Haploidentical Stem Cell Transplantation: A Gateway to Infrequent Availability of HLA-Matched Related Donors |
| title_full_unstemmed | Haploidentical Stem Cell Transplantation: A Gateway to Infrequent Availability of HLA-Matched Related Donors |
| title_short | Haploidentical Stem Cell Transplantation: A Gateway to Infrequent Availability of HLA-Matched Related Donors |
| title_sort | haploidentical stem cell transplantation a gateway to infrequent availability of hla matched related donors |
| url | http://dx.doi.org/10.1155/2018/2573657 |
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