The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome
Background. Extensive evidence, arising from models of endothelial nitric oxide synthase gene (NOS3)-knockout mice supports the role of endothelial malfunction in the pathogenesis of the metabolic syndrome (MS). Aims. The aim of this study was to evaluate the role of −786T/C polymorphism in the etio...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2011/458750 |
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| author | Blazej Misiak Marta Krolik Anna Kukowka Anna Lewera Przemyslaw Leszczynski Joanna Stankiewicz-Olczyk Ryszard Slezak |
| author_facet | Blazej Misiak Marta Krolik Anna Kukowka Anna Lewera Przemyslaw Leszczynski Joanna Stankiewicz-Olczyk Ryszard Slezak |
| author_sort | Blazej Misiak |
| collection | DOAJ |
| description | Background. Extensive evidence, arising from models of endothelial nitric oxide synthase gene (NOS3)-knockout mice supports the role of endothelial malfunction in the pathogenesis of the metabolic syndrome (MS). Aims. The aim of this study was to evaluate the role of −786T/C polymorphism in the etiology of MS and assess previously reported interaction with cigarette smoking. Methods. Based on International Diabetes Federation 2005 criteria, we recruited randomly 152 subjects with MS and 75 subjects without MS. Results. Allelic and genotype frequencies did not differ significantly between both groups. Total cholesterol level (CHOLT) and intima-media thickness of carotid arteries were significantly higher in −786CC homozygotes, in comparison with −786TC and −786TT patients. Regarding current smoking status, −786C allele was associated with higher CHOLT than −786T allele. Conclusion. Our study indicates the putative role of −786T/C polymorphism in the development of hypercholesterolemia, in patients with MS, which might be enhanced by cigarette smoking. |
| format | Article |
| id | doaj-art-387dc517a34743dbb1645b438dba566d |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-387dc517a34743dbb1645b438dba566d2025-02-03T05:58:39ZengWileyInternational Journal of Endocrinology1687-83371687-83452011-01-01201110.1155/2011/458750458750The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic SyndromeBlazej Misiak0Marta Krolik1Anna Kukowka2Anna Lewera3Przemyslaw Leszczynski4Joanna Stankiewicz-Olczyk5Ryszard Slezak6Department of Genetics, Wroclaw Medical University, 50-368 Wroclaw, PolandDepartment of Genetics, Wroclaw Medical University, 50-368 Wroclaw, PolandDepartment of Genetics, Wroclaw Medical University, 50-368 Wroclaw, PolandDepartment of Genetics, Wroclaw Medical University, 50-368 Wroclaw, PolandDepartment of Genetics, Wroclaw Medical University, 50-368 Wroclaw, PolandCopper Health Centre, The Outpatient Clinic of Endocrinology, 59-300 Lubin, PolandDepartment of Genetics, Wroclaw Medical University, 50-368 Wroclaw, PolandBackground. Extensive evidence, arising from models of endothelial nitric oxide synthase gene (NOS3)-knockout mice supports the role of endothelial malfunction in the pathogenesis of the metabolic syndrome (MS). Aims. The aim of this study was to evaluate the role of −786T/C polymorphism in the etiology of MS and assess previously reported interaction with cigarette smoking. Methods. Based on International Diabetes Federation 2005 criteria, we recruited randomly 152 subjects with MS and 75 subjects without MS. Results. Allelic and genotype frequencies did not differ significantly between both groups. Total cholesterol level (CHOLT) and intima-media thickness of carotid arteries were significantly higher in −786CC homozygotes, in comparison with −786TC and −786TT patients. Regarding current smoking status, −786C allele was associated with higher CHOLT than −786T allele. Conclusion. Our study indicates the putative role of −786T/C polymorphism in the development of hypercholesterolemia, in patients with MS, which might be enhanced by cigarette smoking.http://dx.doi.org/10.1155/2011/458750 |
| spellingShingle | Blazej Misiak Marta Krolik Anna Kukowka Anna Lewera Przemyslaw Leszczynski Joanna Stankiewicz-Olczyk Ryszard Slezak The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome International Journal of Endocrinology |
| title | The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome |
| title_full | The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome |
| title_fullStr | The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome |
| title_full_unstemmed | The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome |
| title_short | The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome |
| title_sort | role of 786t c polymorphism in the endothelial nitric oxide synthase gene in males with clinical and biochemical features of the metabolic syndrome |
| url | http://dx.doi.org/10.1155/2011/458750 |
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