Association of Cancer and the Risk of Developing Atrial Fibrillation: A Systematic Review and Meta-Analysis
Aims. Previous studies have demonstrated epidemiological evidence for an association between cancer and the development of new-onset atrial fibrillation (AF). However, these results have been conflicting. This systematic review and meta-analysis was conducted to examine the relationship between canc...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2019/8985273 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549430644965376 |
|---|---|
| author | Ming Yuan Zhiwei Zhang Gary Tse Xiaojin Feng Panagiotis Korantzopoulos Konstantinos P. Letsas Bryan P. Yan William K. K. Wu Huilai Zhang Guangping Li Tong Liu Yunlong Xia |
| author_facet | Ming Yuan Zhiwei Zhang Gary Tse Xiaojin Feng Panagiotis Korantzopoulos Konstantinos P. Letsas Bryan P. Yan William K. K. Wu Huilai Zhang Guangping Li Tong Liu Yunlong Xia |
| author_sort | Ming Yuan |
| collection | DOAJ |
| description | Aims. Previous studies have demonstrated epidemiological evidence for an association between cancer and the development of new-onset atrial fibrillation (AF). However, these results have been conflicting. This systematic review and meta-analysis was conducted to examine the relationship between cancer and the risk of developing atrial fibrillation. Methods. PubMed and Web of Science were searched for publications examining the association between cancer and atrial fibrillation risk published until June 2017. Adjusted odds ratios (ORs) or hazard ratios (HRs) and 95% CI were extracted and pooled. Results. A total of five studies involving 5,889,234 subjects were included in this meta-analysis. Solid cancer patients are at higher risk developing atrial fibrillation compared to noncancer patients (OR 1.47, 95% CI 1.31 to 1.66, p<0.00001; I2 = 67%, p=0.02). The risk of atrial fibrillation was highest within 90 days of cancer diagnosis (OR 7.62, 95% CI 3.08 to 18.88, p<0.00001) and this risk diminished with time. Conclusions. The risk of AF was highest within 90 days of cancer diagnosis. We should take into account the increased risk of atrial fibrillation development and, after this, study the embolic risk and potential indication of oral anticoagulation. |
| format | Article |
| id | doaj-art-386cbd26d2bf4b6dba747d3fbd07f734 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-386cbd26d2bf4b6dba747d3fbd07f7342025-02-03T06:11:17ZengWileyCardiology Research and Practice2090-80162090-05972019-01-01201910.1155/2019/89852738985273Association of Cancer and the Risk of Developing Atrial Fibrillation: A Systematic Review and Meta-AnalysisMing Yuan0Zhiwei Zhang1Gary Tse2Xiaojin Feng3Panagiotis Korantzopoulos4Konstantinos P. Letsas5Bryan P. Yan6William K. K. Wu7Huilai Zhang8Guangping Li9Tong Liu10Yunlong Xia11Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, ChinaTianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, ChinaDepartment of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, SAR, ChinaTianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, ChinaFirst Department of Cardiology, University Hospital of Ioannina, Ioannina, GreeceSecond Department of Cardiology, Laboratory of Cardiac Electrophysiology, Evangelismos General Hospital of Athens, Athens, GreeceDepartment of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, SAR, ChinaDepartment of Anaesthesia and Intensive Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, ChinaDepartment of Lymphoma, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, ChinaTianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, ChinaTianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, ChinaDepartment of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian, ChinaAims. Previous studies have demonstrated epidemiological evidence for an association between cancer and the development of new-onset atrial fibrillation (AF). However, these results have been conflicting. This systematic review and meta-analysis was conducted to examine the relationship between cancer and the risk of developing atrial fibrillation. Methods. PubMed and Web of Science were searched for publications examining the association between cancer and atrial fibrillation risk published until June 2017. Adjusted odds ratios (ORs) or hazard ratios (HRs) and 95% CI were extracted and pooled. Results. A total of five studies involving 5,889,234 subjects were included in this meta-analysis. Solid cancer patients are at higher risk developing atrial fibrillation compared to noncancer patients (OR 1.47, 95% CI 1.31 to 1.66, p<0.00001; I2 = 67%, p=0.02). The risk of atrial fibrillation was highest within 90 days of cancer diagnosis (OR 7.62, 95% CI 3.08 to 18.88, p<0.00001) and this risk diminished with time. Conclusions. The risk of AF was highest within 90 days of cancer diagnosis. We should take into account the increased risk of atrial fibrillation development and, after this, study the embolic risk and potential indication of oral anticoagulation.http://dx.doi.org/10.1155/2019/8985273 |
| spellingShingle | Ming Yuan Zhiwei Zhang Gary Tse Xiaojin Feng Panagiotis Korantzopoulos Konstantinos P. Letsas Bryan P. Yan William K. K. Wu Huilai Zhang Guangping Li Tong Liu Yunlong Xia Association of Cancer and the Risk of Developing Atrial Fibrillation: A Systematic Review and Meta-Analysis Cardiology Research and Practice |
| title | Association of Cancer and the Risk of Developing Atrial Fibrillation: A Systematic Review and Meta-Analysis |
| title_full | Association of Cancer and the Risk of Developing Atrial Fibrillation: A Systematic Review and Meta-Analysis |
| title_fullStr | Association of Cancer and the Risk of Developing Atrial Fibrillation: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Association of Cancer and the Risk of Developing Atrial Fibrillation: A Systematic Review and Meta-Analysis |
| title_short | Association of Cancer and the Risk of Developing Atrial Fibrillation: A Systematic Review and Meta-Analysis |
| title_sort | association of cancer and the risk of developing atrial fibrillation a systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2019/8985273 |
| work_keys_str_mv | AT mingyuan associationofcancerandtheriskofdevelopingatrialfibrillationasystematicreviewandmetaanalysis AT zhiweizhang associationofcancerandtheriskofdevelopingatrialfibrillationasystematicreviewandmetaanalysis AT garytse associationofcancerandtheriskofdevelopingatrialfibrillationasystematicreviewandmetaanalysis AT xiaojinfeng associationofcancerandtheriskofdevelopingatrialfibrillationasystematicreviewandmetaanalysis AT panagiotiskorantzopoulos associationofcancerandtheriskofdevelopingatrialfibrillationasystematicreviewandmetaanalysis AT konstantinospletsas associationofcancerandtheriskofdevelopingatrialfibrillationasystematicreviewandmetaanalysis AT bryanpyan associationofcancerandtheriskofdevelopingatrialfibrillationasystematicreviewandmetaanalysis AT williamkkwu associationofcancerandtheriskofdevelopingatrialfibrillationasystematicreviewandmetaanalysis AT huilaizhang associationofcancerandtheriskofdevelopingatrialfibrillationasystematicreviewandmetaanalysis AT guangpingli associationofcancerandtheriskofdevelopingatrialfibrillationasystematicreviewandmetaanalysis AT tongliu associationofcancerandtheriskofdevelopingatrialfibrillationasystematicreviewandmetaanalysis AT yunlongxia associationofcancerandtheriskofdevelopingatrialfibrillationasystematicreviewandmetaanalysis |