Epidemiology of pediatric dengue virus infection, Scenario from a tertiary level hospital in Bangladesh
Background: Dengue fever is the most rapidly spreading mosquito-borne disease and has grown to be a major public health issue, especially in tropical nations like Bangladesh. Globally, children, adolescents, and young adults bear the largest burden of Dengue; the infection rate is highest among infa...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Journal of Infection and Public Health |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034125000334 |
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| author | Kinkar Ghosh Selim Reza Tony Khaleda Islam Reaz Mobarak Md. Jahangir Alam Md. Kamruzzaman Sumaira Alam Muhammad Talha Abdullah Al Faisal Nahidul Islam Md Mobarok Hossain Mst. Noorjahan Begum Mustafizur Rahman |
| author_facet | Kinkar Ghosh Selim Reza Tony Khaleda Islam Reaz Mobarak Md. Jahangir Alam Md. Kamruzzaman Sumaira Alam Muhammad Talha Abdullah Al Faisal Nahidul Islam Md Mobarok Hossain Mst. Noorjahan Begum Mustafizur Rahman |
| author_sort | Kinkar Ghosh |
| collection | DOAJ |
| description | Background: Dengue fever is the most rapidly spreading mosquito-borne disease and has grown to be a major public health issue, especially in tropical nations like Bangladesh. Globally, children, adolescents, and young adults bear the largest burden of Dengue; the infection rate is highest among infants. However, the epidemiology of pediatric dengue virus infection has been poorly explored in Bangladesh. Materials and methods: This study was carried out at the Bangladesh Shishu Hospital & Institute from July to October 2023. Among 1102 admitted patients, 722 who were positive for dengue rapid test were enrolled. Results: The highest number of positive patients were 1–5 years old (38 %) followed by 5–10 years (32 %). Vomiting (49 %) was most common after fever (100 %). 71 % of patients showed warning signs, with 17 deaths. All patients received antibiotics, and the number of different antibiotics increased with hospital stay. Real-time RT-PCR was conducted on purposively selected 104 rapid test positives and 50 negatives for serotyping. DENV-2 was the most predominant serotype (80 %), followed by DENV-3 (20 %). Conclusion: This study underscored the need for targeted public health interventions, especially for children with warning signs, to address the high burden of pediatric dengue infection in Bangladesh. |
| format | Article |
| id | doaj-art-38596af6fff64fc9827da40055732fc3 |
| institution | Kabale University |
| issn | 1876-0341 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj-art-38596af6fff64fc9827da40055732fc32025-02-06T05:11:27ZengElsevierJournal of Infection and Public Health1876-03412025-04-01184102684Epidemiology of pediatric dengue virus infection, Scenario from a tertiary level hospital in BangladeshKinkar Ghosh0Selim Reza Tony1Khaleda Islam2Reaz Mobarak3Md. Jahangir Alam4Md. Kamruzzaman5Sumaira Alam6Muhammad Talha7Abdullah Al Faisal8Nahidul Islam9Md Mobarok Hossain10Mst. Noorjahan Begum11Mustafizur Rahman12Bangladesh Shishu Hospital and Institutes, Dhaka, BangladeshVirology Laboratory, Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Mohakhali, Dhaka 1212, BangladeshInstitute of Nutrition and Food Science (INFS), University of Dhaka, Dhaka 1000, BangladeshBangladesh Shishu Hospital and Institutes, Dhaka, BangladeshBangladesh Shishu Hospital and Institutes, Dhaka, BangladeshBangladesh Shishu Hospital and Institutes, Dhaka, BangladeshBangladesh Shishu Hospital and Institutes, Dhaka, BangladeshVirology Laboratory, Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Mohakhali, Dhaka 1212, BangladeshVirology Laboratory, Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Mohakhali, Dhaka 1212, BangladeshVirology Laboratory, Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Mohakhali, Dhaka 1212, BangladeshGenome Centre, Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Mohakhali, Dhaka 1212, BangladeshVirology Laboratory, Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Mohakhali, Dhaka 1212, BangladeshVirology Laboratory, Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Mohakhali, Dhaka 1212, Bangladesh; Genome Centre, Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Mohakhali, Dhaka 1212, Bangladesh; Correspondence to: Virology Laboratory, Infectious Diseases Division, International Centre for Diarrheal Disease Research, Bangladesh (icddr,b), 68, Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka 1212, Bangladesh.Background: Dengue fever is the most rapidly spreading mosquito-borne disease and has grown to be a major public health issue, especially in tropical nations like Bangladesh. Globally, children, adolescents, and young adults bear the largest burden of Dengue; the infection rate is highest among infants. However, the epidemiology of pediatric dengue virus infection has been poorly explored in Bangladesh. Materials and methods: This study was carried out at the Bangladesh Shishu Hospital & Institute from July to October 2023. Among 1102 admitted patients, 722 who were positive for dengue rapid test were enrolled. Results: The highest number of positive patients were 1–5 years old (38 %) followed by 5–10 years (32 %). Vomiting (49 %) was most common after fever (100 %). 71 % of patients showed warning signs, with 17 deaths. All patients received antibiotics, and the number of different antibiotics increased with hospital stay. Real-time RT-PCR was conducted on purposively selected 104 rapid test positives and 50 negatives for serotyping. DENV-2 was the most predominant serotype (80 %), followed by DENV-3 (20 %). Conclusion: This study underscored the need for targeted public health interventions, especially for children with warning signs, to address the high burden of pediatric dengue infection in Bangladesh.http://www.sciencedirect.com/science/article/pii/S1876034125000334Dengue virus serotypesPediatric DengueDengue hemorrhagic fever (DHF)Co-infectionReal-time RT-PCR |
| spellingShingle | Kinkar Ghosh Selim Reza Tony Khaleda Islam Reaz Mobarak Md. Jahangir Alam Md. Kamruzzaman Sumaira Alam Muhammad Talha Abdullah Al Faisal Nahidul Islam Md Mobarok Hossain Mst. Noorjahan Begum Mustafizur Rahman Epidemiology of pediatric dengue virus infection, Scenario from a tertiary level hospital in Bangladesh Journal of Infection and Public Health Dengue virus serotypes Pediatric Dengue Dengue hemorrhagic fever (DHF) Co-infection Real-time RT-PCR |
| title | Epidemiology of pediatric dengue virus infection, Scenario from a tertiary level hospital in Bangladesh |
| title_full | Epidemiology of pediatric dengue virus infection, Scenario from a tertiary level hospital in Bangladesh |
| title_fullStr | Epidemiology of pediatric dengue virus infection, Scenario from a tertiary level hospital in Bangladesh |
| title_full_unstemmed | Epidemiology of pediatric dengue virus infection, Scenario from a tertiary level hospital in Bangladesh |
| title_short | Epidemiology of pediatric dengue virus infection, Scenario from a tertiary level hospital in Bangladesh |
| title_sort | epidemiology of pediatric dengue virus infection scenario from a tertiary level hospital in bangladesh |
| topic | Dengue virus serotypes Pediatric Dengue Dengue hemorrhagic fever (DHF) Co-infection Real-time RT-PCR |
| url | http://www.sciencedirect.com/science/article/pii/S1876034125000334 |
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