The splicing factor Acin1 is essential for embryonic development but has limited effects on muscle structure and homeostasis

The splicing factor Acin1 is essential for embryonic development but has limited effects on muscle structure and homeostasis

Abstract Apoptotic chromatin condensation inducer 1 (Acin1) is an RNA-binding protein involved in the regulation of alternative splicing, but its physiological function remains unclear. Global deletion of Acin1 causes embryonic lethality around E11.5, with mutants exhibiting developmental delays and...

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Bibliographic Details
Main Authors: Mamoru Aoto, Hiroshi Sakai, Naohito Tokunaga, Mei Miyazaki, Takeshi Kiyoi, Nobutaka Ohkubo, Yuuki Imai, Noriaki Mitsuda
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Acin1
Alternative splicing
Embryonic development
Muscle damage
Muscle regeneration
Online Access:https://doi.org/10.1038/s41598-025-98851-x
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https://doi.org/10.1038/s41598-025-98851-x

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