Striatal cell-type–specific molecular signatures reveal potential therapeutic targets in a model of dystonia

Striatal cell-type–specific molecular signatures reveal potential therapeutic targets in a model of dystonia

Abnormal dopamine neurotransmission and striatal dysfunction is implicated in many forms of dystonia, yet the underlying molecular processes remain unknown. Here, we identified thousands of dysregulated genes within striatal spiny projection neuron (SPN) subtypes in a genetic mouse model of DOPA-res...

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Bibliographic Details
Main Authors: Kaitlyn M. Roman, Ashok R. Dinasarapu, Suraj Cherian, Xueliang Fan, Yuping Donsante, Nivetha Aravind, C. Savio Chan, H.A. Jinnah, Ellen J. Hess
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Neurobiology of Disease
Subjects:
MLi-2
RNA-seq
Parkinson's disease
Translatome
Medium spiny neuron
D1 dopamine receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125001974
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http://www.sciencedirect.com/science/article/pii/S0969996125001974

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