Smoking as a risk factor for rheumatoid arthritis: predominant association with IgA autoantibodies – comprehensive analysis of anti-modified protein antibodies with smoking and genetic risk factors in rheumatoid arthritis

Smoking as a risk factor for rheumatoid arthritis: predominant association with IgA autoantibodies – comprehensive analysis of anti-modified protein antibodies with smoking and genetic risk factors in rheumatoid arthritis

Abstract Background Rheumatoid arthritis (RA) is an autoimmune disease characterized by the presence of autoantibodies against modified proteins, known as anti-modified protein autoantibodies (AMPAs). While the relationship between different AMPA isotypes and various risk factors remains poorly unde...

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Main Authors: Tineke J. van Wesemael, Fraser R. Morton, Judith W. Heutz, Marc P. Maurits, Annemarie L. Dorjée, Duncan Porter, Tom W. J. Huizinga, Karim Raza, Rene E. M. Toes, Rachel Knevel, Pascal H. P. de Jong, Anna Svärd, Diane van der Woude
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
Anti-modified protein antibodies
Anti-acetylated protein antibodies
Anti-citrullinated protein antibodies
Smoking
Genetic risk factors
Online Access:https://doi.org/10.1186/s13075-025-03543-6
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https://doi.org/10.1186/s13075-025-03543-6

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