A strategy for selective screening of dual-target bioactive compounds against hypertrophic scar through inhibiting angiotensin II type 1 receptor while stimulating type 2 receptor from Chinese herbs

A strategy for selective screening of dual-target bioactive compounds against hypertrophic scar through inhibiting angiotensin II type 1 receptor while stimulating type 2 receptor from Chinese herbs

Abstract Background Cutaneous hypertrophic scar is a fibro-proliferative hard-curing disease. Recent studies have proved that antagonists of angiotensin II type 1 receptor (AT1R) and agonists of type 2 receptor (AT2R) were able to relieve hypertrophic scar. Therefore, establishing new methods to pur...

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Bibliographic Details
Main Authors: Lejing Qu, Meizhi Jiao, Zilong Zhang, Yuanyuan Ou, Xue Zhao, Yajun Zhang, Xinfeng Zhao
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Chinese Medicine
Subjects:
Rhei Radix et Rhizoma
Drug discovery
Multi-target drugs
Hypertrophic scar
Angiotensin receptor
Immobilized receptor
Online Access:https://doi.org/10.1186/s13020-025-01065-6
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https://doi.org/10.1186/s13020-025-01065-6

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