Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models.

Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models.

Bioenergetic abnormalities and metabolic dysfunctionoccur in amyotrophic lateral sclerosis (ALS) patients and genetic mouse models. However, whether metabolic dysfunction occurs earlyin ALS pathophysiology linked to different ALS genes remains unclear.Here, we investigatedAMP-activated protein kinas...

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Bibliographic Details
Main Authors: Nirma D Perera, Rebecca K Sheean, John W Scott, Bruce E Kemp, Malcolm K Horne, Bradley J Turner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090449&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090449&type=printable

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