Statins Increase the Frequency of Circulating CD4+FOXP3+ Regulatory T Cells in Healthy Individuals
Statins have been shown to modulate the number and the suppressive function of CD4+FOXP3+ T cells (Treg) in inflammatory conditions. However, it is not well established whether statin could also affect Treg in absence of inflammation. To address this question, eighteen normocholesterolemic male subj...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/762506 |
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| author | Ana Lucía Rodríguez-Perea Carlos J. Montoya Sven Olek Claire A. Chougnet Paula A. Velilla |
| author_facet | Ana Lucía Rodríguez-Perea Carlos J. Montoya Sven Olek Claire A. Chougnet Paula A. Velilla |
| author_sort | Ana Lucía Rodríguez-Perea |
| collection | DOAJ |
| description | Statins have been shown to modulate the number and the suppressive function of CD4+FOXP3+ T cells (Treg) in inflammatory conditions. However, it is not well established whether statin could also affect Treg in absence of inflammation. To address this question, eighteen normocholesterolemic male subjects were treated with lovastatin or atorvastatin daily for 45 days. The frequency and phenotype of circulating
Treg were evaluated at days 0, 7, 30, and 45. mRNA levels of FOXP3, IDO, TGF-β, and IL-10 were measured in CD4+ T cells.
We found that both statins significantly increased Treg frequency and FOXP3 mRNA levels at day 30. At day 45, Treg numbers returned to baseline values;
however, TGF-β and FOXP3 mRNA levels remained high, accompanied by increased percentages of CTLA-4- and GITR-expressing Treg. Treg Ki-67
expression was decreased upon statin treatment. Treg frequency positively correlated with plasma levels of high-density lipoprotein cholesterol (HDL-c),
suggesting a role for HDL-c in Treg homeostasis. Therefore, statins appear to have inflammation-independent immune-modulatory effects.
Thus, the increase in Treg cells frequency likely contributes to immunomodulatory effect of statins, even in healthy individuals. |
| format | Article |
| id | doaj-art-37cefabd4ba64928a362c31f76b2583a |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-37cefabd4ba64928a362c31f76b2583a2025-02-03T01:22:13ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/762506762506Statins Increase the Frequency of Circulating CD4+FOXP3+ Regulatory T Cells in Healthy IndividualsAna Lucía Rodríguez-Perea0Carlos J. Montoya1Sven Olek2Claire A. Chougnet3Paula A. Velilla4Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia (UdeA), Calle 70 No. 52-21, Medellín, ColombiaGrupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia (UdeA), Calle 70 No. 52-21, Medellín, ColombiaEpiontis GmbH, 12489 Berlin, GermanyDivision of Immunobiology, Department of Pediatrics, Cincinnati Children’s Hospital Research Foundation, Cincinnati, OH 45229, USAGrupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia (UdeA), Calle 70 No. 52-21, Medellín, ColombiaStatins have been shown to modulate the number and the suppressive function of CD4+FOXP3+ T cells (Treg) in inflammatory conditions. However, it is not well established whether statin could also affect Treg in absence of inflammation. To address this question, eighteen normocholesterolemic male subjects were treated with lovastatin or atorvastatin daily for 45 days. The frequency and phenotype of circulating Treg were evaluated at days 0, 7, 30, and 45. mRNA levels of FOXP3, IDO, TGF-β, and IL-10 were measured in CD4+ T cells. We found that both statins significantly increased Treg frequency and FOXP3 mRNA levels at day 30. At day 45, Treg numbers returned to baseline values; however, TGF-β and FOXP3 mRNA levels remained high, accompanied by increased percentages of CTLA-4- and GITR-expressing Treg. Treg Ki-67 expression was decreased upon statin treatment. Treg frequency positively correlated with plasma levels of high-density lipoprotein cholesterol (HDL-c), suggesting a role for HDL-c in Treg homeostasis. Therefore, statins appear to have inflammation-independent immune-modulatory effects. Thus, the increase in Treg cells frequency likely contributes to immunomodulatory effect of statins, even in healthy individuals.http://dx.doi.org/10.1155/2015/762506 |
| spellingShingle | Ana Lucía Rodríguez-Perea Carlos J. Montoya Sven Olek Claire A. Chougnet Paula A. Velilla Statins Increase the Frequency of Circulating CD4+FOXP3+ Regulatory T Cells in Healthy Individuals Journal of Immunology Research |
| title | Statins Increase the Frequency of Circulating CD4+FOXP3+ Regulatory T Cells in Healthy Individuals |
| title_full | Statins Increase the Frequency of Circulating CD4+FOXP3+ Regulatory T Cells in Healthy Individuals |
| title_fullStr | Statins Increase the Frequency of Circulating CD4+FOXP3+ Regulatory T Cells in Healthy Individuals |
| title_full_unstemmed | Statins Increase the Frequency of Circulating CD4+FOXP3+ Regulatory T Cells in Healthy Individuals |
| title_short | Statins Increase the Frequency of Circulating CD4+FOXP3+ Regulatory T Cells in Healthy Individuals |
| title_sort | statins increase the frequency of circulating cd4 foxp3 regulatory t cells in healthy individuals |
| url | http://dx.doi.org/10.1155/2015/762506 |
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