Hormone correction of dysfunctional metabolic gene expression in stem cell-derived liver tissue

Hormone correction of dysfunctional metabolic gene expression in stem cell-derived liver tissue

Abstract The increase in metabolic dysfunction-associated steatotic liver disease (MASLD) and its progression to metabolic dysfunction-associated steatohepatitis (MASH) is a worldwide healthcare challenge. Heterogeneity between men and women in the prevalence and mechanisms of MASLD and MASH is rela...

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Main Authors: Alvile Kasarinaite, Maria Jimenez Ramos, Mariana Beltran-Sierra, Elena F. Sutherland, Pedro Arede Rei, Make Zhao, Ying Chi, Meryam Beniazza, Andrea Corsinotti, Timothy J. Kendall, Neil C. Henderson, Jonathan A. Fallowfield, Philippa T. K. Saunders, David C. Hay
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Stem Cell Research & Therapy
Subjects:
Liver
MASLD
MASH
Fibrosis
Estrogen
Testosterone
Online Access:https://doi.org/10.1186/s13287-025-04238-0
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https://doi.org/10.1186/s13287-025-04238-0

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