Marine natural products as an important source of bioactive substances for non-alcoholic fatty liver disease management
With an estimated global prevalence of 32.4%, non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent chronic liver condition. The marine ecosystem, distinguished by its distinctive environmental characteristics, is a treasure trove of novel lead compounds possessing unique chemica...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Marine Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmars.2024.1523246/full |
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| author | Menglei Shi Menglei Shi Sisi Chen Sisi Chen Yutong Feng Yutong Feng Shiyuan Wang Yuyu Xia Jianlin He |
| author_facet | Menglei Shi Menglei Shi Sisi Chen Sisi Chen Yutong Feng Yutong Feng Shiyuan Wang Yuyu Xia Jianlin He |
| author_sort | Menglei Shi |
| collection | DOAJ |
| description | With an estimated global prevalence of 32.4%, non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent chronic liver condition. The marine ecosystem, distinguished by its distinctive environmental characteristics, is a treasure trove of novel lead compounds possessing unique chemical structures, offering promising avenues for the development of new therapeutic agents or dietary supplement targeting NAFLD. Marine bioactive substances from natural products, such as polysaccharides, polyphenols, polyunsaturated fatty acids, and peptides, have been shown to benefit liver health by alleviating metabolic dysfunction through multiple mechanisms. This paper reviews the effects of marine bioactive substances from various marine entities, including marine fauna, flora, and microorganisms, on the regulation of NAFLD. A brief overview of the predominant pathogenic mechanisms underlying the disease is also provided, thereby establishing a critical link between the therapeutic potential of marine bioactive substances and the management of NAFLD. |
| format | Article |
| id | doaj-art-37bf88e9ee434cf4860f6fb7ade9fe9a |
| institution | Kabale University |
| issn | 2296-7745 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Marine Science |
| spelling | doaj-art-37bf88e9ee434cf4860f6fb7ade9fe9a2025-01-28T05:10:38ZengFrontiers Media S.A.Frontiers in Marine Science2296-77452025-01-011110.3389/fmars.2024.15232461523246Marine natural products as an important source of bioactive substances for non-alcoholic fatty liver disease managementMenglei Shi0Menglei Shi1Sisi Chen2Sisi Chen3Yutong Feng4Yutong Feng5Shiyuan Wang6Yuyu Xia7Jianlin He8School of Advanced Manufacturing, Fuzhou University, Jinjiang, ChinaTechnology Innovation Center for Exploitation of Marine Biological Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen, ChinaTechnology Innovation Center for Exploitation of Marine Biological Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen, ChinaSchool of Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, ChinaTechnology Innovation Center for Exploitation of Marine Biological Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen, ChinaSchool of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, ChinaTechnology Innovation Center for Exploitation of Marine Biological Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen, ChinaTechnology Innovation Center for Exploitation of Marine Biological Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen, ChinaTechnology Innovation Center for Exploitation of Marine Biological Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen, ChinaWith an estimated global prevalence of 32.4%, non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent chronic liver condition. The marine ecosystem, distinguished by its distinctive environmental characteristics, is a treasure trove of novel lead compounds possessing unique chemical structures, offering promising avenues for the development of new therapeutic agents or dietary supplement targeting NAFLD. Marine bioactive substances from natural products, such as polysaccharides, polyphenols, polyunsaturated fatty acids, and peptides, have been shown to benefit liver health by alleviating metabolic dysfunction through multiple mechanisms. This paper reviews the effects of marine bioactive substances from various marine entities, including marine fauna, flora, and microorganisms, on the regulation of NAFLD. A brief overview of the predominant pathogenic mechanisms underlying the disease is also provided, thereby establishing a critical link between the therapeutic potential of marine bioactive substances and the management of NAFLD.https://www.frontiersin.org/articles/10.3389/fmars.2024.1523246/fullmetabolic disorderschronic liver diseaselipidslead compoundsdietary supplements |
| spellingShingle | Menglei Shi Menglei Shi Sisi Chen Sisi Chen Yutong Feng Yutong Feng Shiyuan Wang Yuyu Xia Jianlin He Marine natural products as an important source of bioactive substances for non-alcoholic fatty liver disease management Frontiers in Marine Science metabolic disorders chronic liver disease lipids lead compounds dietary supplements |
| title | Marine natural products as an important source of bioactive substances for non-alcoholic fatty liver disease management |
| title_full | Marine natural products as an important source of bioactive substances for non-alcoholic fatty liver disease management |
| title_fullStr | Marine natural products as an important source of bioactive substances for non-alcoholic fatty liver disease management |
| title_full_unstemmed | Marine natural products as an important source of bioactive substances for non-alcoholic fatty liver disease management |
| title_short | Marine natural products as an important source of bioactive substances for non-alcoholic fatty liver disease management |
| title_sort | marine natural products as an important source of bioactive substances for non alcoholic fatty liver disease management |
| topic | metabolic disorders chronic liver disease lipids lead compounds dietary supplements |
| url | https://www.frontiersin.org/articles/10.3389/fmars.2024.1523246/full |
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