Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in Mice
We previously reported that radon inhalation activates antioxidative functions in the liver and inhibits carbon tetrachloride-induced hepatopathy in mice. In addition, it has been reported that reactive oxygen species contribute to alcohol-induced hepatopathy. In this study, we examined the inhibito...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/382801 |
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| _version_ | 1832566194005082112 |
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| author | Teruaki Toyota Takahiro Kataoka Yuichi Nishiyama Takehito Taguchi Kiyonori Yamaoka |
| author_facet | Teruaki Toyota Takahiro Kataoka Yuichi Nishiyama Takehito Taguchi Kiyonori Yamaoka |
| author_sort | Teruaki Toyota |
| collection | DOAJ |
| description | We previously reported that radon inhalation activates antioxidative functions in the liver and inhibits carbon tetrachloride-induced hepatopathy in mice. In addition, it has been reported that reactive oxygen species contribute to alcohol-induced hepatopathy. In this study, we examined the inhibitory effects of radon inhalation on acute alcohol-induced hepatopathy in mice. C57BL/6J mice were subjected to intraperitoneal injection of 50% alcohol (5 g/kg bodyweight) after inhaling approximately 4000 Bq/m3 radon for 24 h. Alcohol administration significantly increased the activities of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) in serum, and the levels of triglyceride and lipid peroxide in the liver, suggesting acute alcohol-induced hepatopathy. Radon inhalation activated antioxidative functions in the liver. Furthermore, pretreatment with radon inhibited the depression of hepatic functions and antioxidative functions. These findings suggested that radon inhalation activated antioxidative functions in the liver and inhibited acute alcohol-induced hepatopathy in mice. |
| format | Article |
| id | doaj-art-37655e067e71491f83c8d1f7dbdf183d |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-37655e067e71491f83c8d1f7dbdf183d2025-02-03T01:04:48ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/382801382801Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in MiceTeruaki Toyota0Takahiro Kataoka1Yuichi Nishiyama2Takehito Taguchi3Kiyonori Yamaoka4Graduate School of Health Sciences, Okayama University, 5-1 Shikata-cho, 2-chome, Okayama 700-8558, JapanGraduate School of Health Sciences, Okayama University, 5-1 Shikata-cho, 2-chome, Okayama 700-8558, JapanGraduate School of Health Sciences, Okayama University, 5-1 Shikata-cho, 2-chome, Okayama 700-8558, JapanGraduate School of Health Sciences, Okayama University, 5-1 Shikata-cho, 2-chome, Okayama 700-8558, JapanGraduate School of Health Sciences, Okayama University, 5-1 Shikata-cho, 2-chome, Okayama 700-8558, JapanWe previously reported that radon inhalation activates antioxidative functions in the liver and inhibits carbon tetrachloride-induced hepatopathy in mice. In addition, it has been reported that reactive oxygen species contribute to alcohol-induced hepatopathy. In this study, we examined the inhibitory effects of radon inhalation on acute alcohol-induced hepatopathy in mice. C57BL/6J mice were subjected to intraperitoneal injection of 50% alcohol (5 g/kg bodyweight) after inhaling approximately 4000 Bq/m3 radon for 24 h. Alcohol administration significantly increased the activities of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) in serum, and the levels of triglyceride and lipid peroxide in the liver, suggesting acute alcohol-induced hepatopathy. Radon inhalation activated antioxidative functions in the liver. Furthermore, pretreatment with radon inhibited the depression of hepatic functions and antioxidative functions. These findings suggested that radon inhalation activated antioxidative functions in the liver and inhibited acute alcohol-induced hepatopathy in mice.http://dx.doi.org/10.1155/2012/382801 |
| spellingShingle | Teruaki Toyota Takahiro Kataoka Yuichi Nishiyama Takehito Taguchi Kiyonori Yamaoka Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in Mice Mediators of Inflammation |
| title | Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in Mice |
| title_full | Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in Mice |
| title_fullStr | Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in Mice |
| title_full_unstemmed | Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in Mice |
| title_short | Inhibitory Effects of Pretreatment with Radon on Acute Alcohol-Induced Hepatopathy in Mice |
| title_sort | inhibitory effects of pretreatment with radon on acute alcohol induced hepatopathy in mice |
| url | http://dx.doi.org/10.1155/2012/382801 |
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