Phytoestrogens in Human Pregnancy
Background. The hormonal milieu associated with pregnancy has become a focus of interest owing to potential links with the developmental origins of health and disease. Phytoestrogens are hormonally active plant-derived chemicals that may have an impact on human reproductive processes. However, devel...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2012/850313 |
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| author | John Jarrell Warren G. Foster David W. Kinniburgh |
| author_facet | John Jarrell Warren G. Foster David W. Kinniburgh |
| author_sort | John Jarrell |
| collection | DOAJ |
| description | Background. The hormonal milieu associated with pregnancy has become a focus of interest owing to potential links with the developmental origins of health and disease. Phytoestrogens are hormonally active plant-derived chemicals that may have an impact on human reproductive processes. However, developmental exposure to phytoestrogens has not been well characterized and thus our objective was to quantify phytoestrogen exposure during pregnancy and lactation. Methods. Women in the second trimester of pregnancy entered the study during counseling for prenatal genetic information. Women who had an indication for a genetic amniocentesis on the basis of late maternal age were approached for inclusion. They completed an environmental questionnaire; a sample of amniotic fluid was collected for karyotype, blood was collected from women during pregnancy and at birth, from the umbilical cord and breast milk. Samples were tested for the presence of daidzein and genistein by GC Mass Spectroscopy. Findings. Phytoestrogens are commonly found in pregnant women’s serum and amniotic fluid during pregnancy. There is a sex difference in the concentrations with higher levels in amniotic fluid containing female fetuses. This difference was not present in maternal serum. Soy ingestion increases amniotic fluid phytoestrogen concentrations in female and male fetuses. The presence and concentrations of phytoestrogens did not differ in relation to common pregnancy complications or preexisting infertility. |
| format | Article |
| id | doaj-art-3764d8a1a7ad4011b7b648f9619fc0d2 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-3764d8a1a7ad4011b7b648f9619fc0d22025-02-03T01:03:48ZengWileyObstetrics and Gynecology International1687-95891687-95972012-01-01201210.1155/2012/850313850313Phytoestrogens in Human PregnancyJohn Jarrell0Warren G. Foster1David W. Kinniburgh2Department of Obstetrics and Gynecology, University of Calgary, 1403 29 NW Street, Calgary, AB, T2N 2T9, CanadaReproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University, Hamilton, ON, L8N 3Z5, CanadaAlberta Centre for Toxicology, University of Calgary, Calgary, AB, T2N 2T9, CanadaBackground. The hormonal milieu associated with pregnancy has become a focus of interest owing to potential links with the developmental origins of health and disease. Phytoestrogens are hormonally active plant-derived chemicals that may have an impact on human reproductive processes. However, developmental exposure to phytoestrogens has not been well characterized and thus our objective was to quantify phytoestrogen exposure during pregnancy and lactation. Methods. Women in the second trimester of pregnancy entered the study during counseling for prenatal genetic information. Women who had an indication for a genetic amniocentesis on the basis of late maternal age were approached for inclusion. They completed an environmental questionnaire; a sample of amniotic fluid was collected for karyotype, blood was collected from women during pregnancy and at birth, from the umbilical cord and breast milk. Samples were tested for the presence of daidzein and genistein by GC Mass Spectroscopy. Findings. Phytoestrogens are commonly found in pregnant women’s serum and amniotic fluid during pregnancy. There is a sex difference in the concentrations with higher levels in amniotic fluid containing female fetuses. This difference was not present in maternal serum. Soy ingestion increases amniotic fluid phytoestrogen concentrations in female and male fetuses. The presence and concentrations of phytoestrogens did not differ in relation to common pregnancy complications or preexisting infertility.http://dx.doi.org/10.1155/2012/850313 |
| spellingShingle | John Jarrell Warren G. Foster David W. Kinniburgh Phytoestrogens in Human Pregnancy Obstetrics and Gynecology International |
| title | Phytoestrogens in Human Pregnancy |
| title_full | Phytoestrogens in Human Pregnancy |
| title_fullStr | Phytoestrogens in Human Pregnancy |
| title_full_unstemmed | Phytoestrogens in Human Pregnancy |
| title_short | Phytoestrogens in Human Pregnancy |
| title_sort | phytoestrogens in human pregnancy |
| url | http://dx.doi.org/10.1155/2012/850313 |
| work_keys_str_mv | AT johnjarrell phytoestrogensinhumanpregnancy AT warrengfoster phytoestrogensinhumanpregnancy AT davidwkinniburgh phytoestrogensinhumanpregnancy |