PRMT1-mediated metabolic reprogramming promotes leukemogenesis

PRMT1-mediated metabolic reprogramming promotes leukemogenesis

Copious expression of protein arginine methyltransferase 1 (PRMT1) is associated with poor survival in many types of cancers, including acute myeloid leukemia. We observed that a specific acute megakaryocytic leukemia (AMKL) cell line (6133) derived from RBM15-MKL1 knock-in mice exhibited heterogene...

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Main Authors: Hairui Su, Yong Sun, Han Guo, Chiao-Wang Sun, Qiuying Chen, Szumam Liu, Anlun Li, Min Gao, Rui Zhao, Glen Raffel, Jian Jin, Cheng-Kui Qu, Michael Yu, Christopher A Klug, George Y Zheng, Scott Ballinger, Matthew Kutny, Long X Zheng, Zechen Chong, Chamara Senevirathne, Steven Gross, Yabing Chen, Minkui Luo, Xinyang Zhao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-08-01
Series:eLife
Subjects:
PRMT1
mitochondria
glycolysis
leukemia
CPT1A
fatty acids
Online Access:https://elifesciences.org/articles/105318
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https://elifesciences.org/articles/105318

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