Indole-3-propionic acid promotes Schwann cell proliferation following peripheral nerve injury by activating the PI3K/AKT pathway

Indole-3-propionic acid promotes Schwann cell proliferation following peripheral nerve injury by activating the PI3K/AKT pathway

The proliferation of Schwann cells (SCs) is integral for axonal regeneration following peripheral nerve injury, and enhancing their proliferation can accelerate axonal regeneration. Indole-3-propionic acid (IPA), a metabolite of tryptophan synthesized by the intestinal microbiota, has potential in a...

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Bibliographic Details
Main Authors: Huimei Zhang, Sijia Wang, Qi Zhang, Xinyu Du, Danyang Xu, Jinkun Wen, Mingrui Jin, Jing Liu, Xiaobao Jin, Mengxia Wang, Li Luo, Lixia Li
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Neurotherapeutics
Subjects:
Indole-3-propionic acid
Schwann cells
Proliferation
Peripheral nerve injury
PI3K/AKT pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S187874792500056X
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