Association between inflammatory indices and preoperative deep vein thrombosis in patients undergoing total joint arthroplasty: a retrospective study
Abstract Background To investigate the association between inflammatory indices-systemic immune-inflammation index (SII), monocyte-lymphocyte ratio (MLR), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and preoperative deep vein thrombosis (DVT) in patients undergoing total joint...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Thrombosis Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12959-024-00682-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585414332907520 |
|---|---|
| author | Xiaojuan Xiong Peng Hu Ting Li Shuang Yu Qingxiang Mao |
| author_facet | Xiaojuan Xiong Peng Hu Ting Li Shuang Yu Qingxiang Mao |
| author_sort | Xiaojuan Xiong |
| collection | DOAJ |
| description | Abstract Background To investigate the association between inflammatory indices-systemic immune-inflammation index (SII), monocyte-lymphocyte ratio (MLR), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and preoperative deep vein thrombosis (DVT) in patients undergoing total joint arthroplasty (TJA). Methods We created the receiver operator characteristic (ROC) curve using the ratios of SII, MLR, NLR, PLR to DVT before TJA, divided the enrolled patients into groups based on the cut-off value, and then analyzed risk factors for DVT before TJA in the multivariate binary logistic regression analysis. Results A total of 2125 patients were enrolled and preoperative DVT occurred in 110 cases (5.18%). Based on the ROC curve, we determined that the cut-off values for SII, MLR, NLR, and PLR were 470*109 /L, 0.306, 2.08, and 127; and the areas under the curve (AUC) were 0.623, 0.601, 0.611, and 0.62. Multivariate binary regression analysis revealed that the risk of preoperative DVT in TJA patients with SII ≥ 470*109/L, MLR ≥ 0.306, PLR ≥ 127, and NLR ≥ 2.08 increased by 2.26 (P < 0.001, 95% confidence interval (CI) [1.52–3.37]), 1.92 (P = 0.002, 95% CI [1.28–2.9]), 2.1 (P < 0.001, 95% CI [1.4–3.16]), and 1.94 (P = 0.002, 95% CI [1.29–2.92]) times, respectively. Age, P < 0.001, odds ratio (OR) = 1.08, 95%CI [1.05–1.10]; corticosteroid use, P = 0.002, OR 3.8, 95% CI [1.94–9.22]). Conclusion We found that higher SII, MLR, NLR, and PLR levels, age, and corticosteroid use were independent risk factors for preoperative DVT in patients undergoing TJA. Clinical trial registration ChiCTR2100054844; Registration Date: 2021.12.28. |
| format | Article |
| id | doaj-art-36da368d41b24a3d8a711da57ad4e4b7 |
| institution | Kabale University |
| issn | 1477-9560 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Thrombosis Journal |
| spelling | doaj-art-36da368d41b24a3d8a711da57ad4e4b72025-01-26T12:48:25ZengBMCThrombosis Journal1477-95602025-01-0123111010.1186/s12959-024-00682-9Association between inflammatory indices and preoperative deep vein thrombosis in patients undergoing total joint arthroplasty: a retrospective studyXiaojuan Xiong0Peng Hu1Ting Li2Shuang Yu3Qingxiang Mao4Department of Anesthesiology, Daping Hospital, Army Medical Center of PLA, Army Medical UniversitySchool of Public Policy and Administration, Chongqing UniversityDepartment of Anesthesiology, Daping Hospital, Army Medical Center of PLA, Army Medical UniversityDepartment of Anesthesiology, Daping Hospital, Army Medical Center of PLA, Army Medical UniversityDepartment of Anesthesiology, Daping Hospital, Army Medical Center of PLA, Army Medical UniversityAbstract Background To investigate the association between inflammatory indices-systemic immune-inflammation index (SII), monocyte-lymphocyte ratio (MLR), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and preoperative deep vein thrombosis (DVT) in patients undergoing total joint arthroplasty (TJA). Methods We created the receiver operator characteristic (ROC) curve using the ratios of SII, MLR, NLR, PLR to DVT before TJA, divided the enrolled patients into groups based on the cut-off value, and then analyzed risk factors for DVT before TJA in the multivariate binary logistic regression analysis. Results A total of 2125 patients were enrolled and preoperative DVT occurred in 110 cases (5.18%). Based on the ROC curve, we determined that the cut-off values for SII, MLR, NLR, and PLR were 470*109 /L, 0.306, 2.08, and 127; and the areas under the curve (AUC) were 0.623, 0.601, 0.611, and 0.62. Multivariate binary regression analysis revealed that the risk of preoperative DVT in TJA patients with SII ≥ 470*109/L, MLR ≥ 0.306, PLR ≥ 127, and NLR ≥ 2.08 increased by 2.26 (P < 0.001, 95% confidence interval (CI) [1.52–3.37]), 1.92 (P = 0.002, 95% CI [1.28–2.9]), 2.1 (P < 0.001, 95% CI [1.4–3.16]), and 1.94 (P = 0.002, 95% CI [1.29–2.92]) times, respectively. Age, P < 0.001, odds ratio (OR) = 1.08, 95%CI [1.05–1.10]; corticosteroid use, P = 0.002, OR 3.8, 95% CI [1.94–9.22]). Conclusion We found that higher SII, MLR, NLR, and PLR levels, age, and corticosteroid use were independent risk factors for preoperative DVT in patients undergoing TJA. Clinical trial registration ChiCTR2100054844; Registration Date: 2021.12.28.https://doi.org/10.1186/s12959-024-00682-9Systemic immune-inflammation indexMonocyte–lymphocyte ratioNeutrophil-lymphocyte ratioPlatelet-lymphocyte ratioTotal joint arthroplastyDeep vein thrombosis |
| spellingShingle | Xiaojuan Xiong Peng Hu Ting Li Shuang Yu Qingxiang Mao Association between inflammatory indices and preoperative deep vein thrombosis in patients undergoing total joint arthroplasty: a retrospective study Thrombosis Journal Systemic immune-inflammation index Monocyte–lymphocyte ratio Neutrophil-lymphocyte ratio Platelet-lymphocyte ratio Total joint arthroplasty Deep vein thrombosis |
| title | Association between inflammatory indices and preoperative deep vein thrombosis in patients undergoing total joint arthroplasty: a retrospective study |
| title_full | Association between inflammatory indices and preoperative deep vein thrombosis in patients undergoing total joint arthroplasty: a retrospective study |
| title_fullStr | Association between inflammatory indices and preoperative deep vein thrombosis in patients undergoing total joint arthroplasty: a retrospective study |
| title_full_unstemmed | Association between inflammatory indices and preoperative deep vein thrombosis in patients undergoing total joint arthroplasty: a retrospective study |
| title_short | Association between inflammatory indices and preoperative deep vein thrombosis in patients undergoing total joint arthroplasty: a retrospective study |
| title_sort | association between inflammatory indices and preoperative deep vein thrombosis in patients undergoing total joint arthroplasty a retrospective study |
| topic | Systemic immune-inflammation index Monocyte–lymphocyte ratio Neutrophil-lymphocyte ratio Platelet-lymphocyte ratio Total joint arthroplasty Deep vein thrombosis |
| url | https://doi.org/10.1186/s12959-024-00682-9 |
| work_keys_str_mv | AT xiaojuanxiong associationbetweeninflammatoryindicesandpreoperativedeepveinthrombosisinpatientsundergoingtotaljointarthroplastyaretrospectivestudy AT penghu associationbetweeninflammatoryindicesandpreoperativedeepveinthrombosisinpatientsundergoingtotaljointarthroplastyaretrospectivestudy AT tingli associationbetweeninflammatoryindicesandpreoperativedeepveinthrombosisinpatientsundergoingtotaljointarthroplastyaretrospectivestudy AT shuangyu associationbetweeninflammatoryindicesandpreoperativedeepveinthrombosisinpatientsundergoingtotaljointarthroplastyaretrospectivestudy AT qingxiangmao associationbetweeninflammatoryindicesandpreoperativedeepveinthrombosisinpatientsundergoingtotaljointarthroplastyaretrospectivestudy |