Genetic associations of plasma metabolites with immune cells in hyperthyroidism revealed by Mendelian randomization and GWAS-sc-eQTLs xQTLbiolinks analysis

Genetic associations of plasma metabolites with immune cells in hyperthyroidism revealed by Mendelian randomization and GWAS-sc-eQTLs xQTLbiolinks analysis

Abstract Mendelian randomization (MR) was employed to investigate the causal relationships between immune cell phenotypes, hyperthyroidism (HD), and potential metabolic mediators. In this study, we acquired 731 immune cell phenotypes from genome-wide association studies (GWAS) (n = 18,622), HD data...

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Bibliographic Details
Main Authors: Yutong Li, Xingyu Song, Yuyang Huang, Sifan Zhou, Linkun Zhong
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
GWAS-sc-eQTLs
Hyperthyroidism
Mendelian randomization
Plasma metabolites
Immune cell phenotypes
Co-localization analysis
Online Access:https://doi.org/10.1038/s41598-025-85664-1
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https://doi.org/10.1038/s41598-025-85664-1

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