Mechanisms of Fetal Programming in Hypertension
Events that occur in the early fetal environment have been linked to long-term health and lifespan consequences in the adult. Intrauterine growth restriction (IUGR), which may occur as a result of nutrient insufficiency, exposure to hormones, or disruptions in placental structure or function, may in...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2012/584831 |
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| _version_ | 1832556055596367872 |
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| author | John Edward Jones Julie A. Jurgens Sarah A. Evans Riley C. Ennis Van Anthony M. Villar Pedro A. Jose |
| author_facet | John Edward Jones Julie A. Jurgens Sarah A. Evans Riley C. Ennis Van Anthony M. Villar Pedro A. Jose |
| author_sort | John Edward Jones |
| collection | DOAJ |
| description | Events that occur in the early fetal environment have been linked to long-term health and lifespan consequences in the adult. Intrauterine growth restriction (IUGR), which may occur as a result of nutrient insufficiency, exposure to hormones, or disruptions in placental structure or function, may induce the fetus to alter its developmental program in order to adapt to the new conditions. IUGR may result in a decrease in the expression of genes that are responsible for nephrogenesis as nutrients are rerouted to the development of more essential organs. Fetal survival under these conditions often results in low birth weight and a deficit in nephron endowment, which are associated with hypertension in adults. Interestingly, male IUGR offspring appear to be more severely affected than females, suggesting that sex hormones may be involved. The processes of fetal programming of hypertension are complex, and we are only beginning to understand the underlying mechanisms. |
| format | Article |
| id | doaj-art-36ba8ee18aef405fb47d9a3c1675bdd3 |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-36ba8ee18aef405fb47d9a3c1675bdd32025-02-03T05:46:22ZengWileyInternational Journal of Pediatrics1687-97401687-97592012-01-01201210.1155/2012/584831584831Mechanisms of Fetal Programming in HypertensionJohn Edward Jones0Julie A. Jurgens1Sarah A. Evans2Riley C. Ennis3Van Anthony M. Villar4Pedro A. Jose5Center for Molecular Physiology Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USACenter for Molecular Physiology Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USACenter for Molecular Physiology Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USACenter for Molecular Physiology Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USACenter for Molecular Physiology Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USACenter for Molecular Physiology Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USAEvents that occur in the early fetal environment have been linked to long-term health and lifespan consequences in the adult. Intrauterine growth restriction (IUGR), which may occur as a result of nutrient insufficiency, exposure to hormones, or disruptions in placental structure or function, may induce the fetus to alter its developmental program in order to adapt to the new conditions. IUGR may result in a decrease in the expression of genes that are responsible for nephrogenesis as nutrients are rerouted to the development of more essential organs. Fetal survival under these conditions often results in low birth weight and a deficit in nephron endowment, which are associated with hypertension in adults. Interestingly, male IUGR offspring appear to be more severely affected than females, suggesting that sex hormones may be involved. The processes of fetal programming of hypertension are complex, and we are only beginning to understand the underlying mechanisms.http://dx.doi.org/10.1155/2012/584831 |
| spellingShingle | John Edward Jones Julie A. Jurgens Sarah A. Evans Riley C. Ennis Van Anthony M. Villar Pedro A. Jose Mechanisms of Fetal Programming in Hypertension International Journal of Pediatrics |
| title | Mechanisms of Fetal Programming in Hypertension |
| title_full | Mechanisms of Fetal Programming in Hypertension |
| title_fullStr | Mechanisms of Fetal Programming in Hypertension |
| title_full_unstemmed | Mechanisms of Fetal Programming in Hypertension |
| title_short | Mechanisms of Fetal Programming in Hypertension |
| title_sort | mechanisms of fetal programming in hypertension |
| url | http://dx.doi.org/10.1155/2012/584831 |
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