Mapping the anatomical and transcriptional landscape of early human fetal ovary development

Mapping the anatomical and transcriptional landscape of early human fetal ovary development

Abstract The complex genetic mechanisms underlying human ovary development can give rise to clinical phenotypes if disrupted, such as Primary (or Premature) Ovarian Insufficiency and Differences of Sex Development. We combine single-nuclei RNA sequencing, bulk RNA sequencing, and micro-focus compute...

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Bibliographic Details
Main Authors: Sinead M. McGlacken-Byrne, Ignacio del Valle, Theodoros Xenakis, Ian C. Simcock, Jenifer P. Suntharalingham, Federica Buonocore, Berta Crespo, Nadjeda Moreno, Danielle Liptrot, Paola Niola, Tony Brooks, Gerard S. Conway, Mehul T. Dattani, Owen J. Arthurs, Nita Solanky, John C. Achermann
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Ovary development
Ovary function
Ovarian insufficiency
Transcriptomics
Micro-focus computed tomography
Online Access:https://doi.org/10.1038/s41598-025-96135-y
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