脂质代谢组与卒中的因果关系:系统孟德尔随机化研究Causal Relationship between Lipid Metabolome and Stroke: A Systematic Mendelian Randomization Study

目的 脂质代谢异常与卒中的发生发展密切相关。本研究旨在探究脂质代谢组与卒中及其亚型的因果关联,解析脂蛋白成分对卒中的影响。 方法 基于213种脂质代谢指标以及全因卒中(any stroke,AS)、全因缺血性卒中(any ischemic stroke,AIS)及其3种亚型——大动脉型卒中(large artery stroke,LAS)、心源性栓塞型卒中(cardioembolic stroke,CES)和小血管型卒中(small vessel stroke,SVS)的GWAS,通过单变量孟德尔随机化(Mendelian randomization,MR)方法初步筛选与卒中存在潜在因果...

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Main Author: 姜明慧,许喆,石延枫,张杰,李昊,程丝 (JIANG Minghui, XU Zhe, SHI Yanfeng, ZHANG Jie, LI Hao, CHENG Si )
Format: Article
Language:zho
Published: Editorial Department of Chinese Journal of Stroke 2025-06-01
Series:Zhongguo cuzhong zazhi
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Online Access:https://www.chinastroke.org.cn/CN/10.3969/j.issn.1673-5765.2025.06.003
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