The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs
Tissue inhibitors of matrix metalloproteinases (TIMP) are a family of four endogenous proteins that primarily function to inhibit the activities of proteases such as the matrix metalloproteinases (MMP). Altered MMP/TIMP ratios are frequently observed in several human diseases. During aging and disea...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2022/3632764 |
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| _version_ | 1832552840516599808 |
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| author | Louis Costanzo Brian Soto Richard Meier Patrick Geraghty |
| author_facet | Louis Costanzo Brian Soto Richard Meier Patrick Geraghty |
| author_sort | Louis Costanzo |
| collection | DOAJ |
| description | Tissue inhibitors of matrix metalloproteinases (TIMP) are a family of four endogenous proteins that primarily function to inhibit the activities of proteases such as the matrix metalloproteinases (MMP). Altered MMP/TIMP ratios are frequently observed in several human diseases. During aging and disease progression, the extracellular matrix (ECM) undergoes structural changes in which elastin and collagens serve an essential role. MMPs and TIMPs significantly influence the ECM. Classically, elevated levels of TIMPs are suggested to result in ECM accumulation leading to fibrosis, whereas loss of TIMP responses leads to enhanced matrix proteolysis. Here, we outline the known roles of the most abundant TIMP, TIMP2, in pulmonary diseases but also discuss future perspectives in TIMP2 research that could impact the lungs. TIMP2 directly inhibits MMPs, in particular MMP2, but TIMP2 is also required for the activation of MMP2 through its interaction with MMP14. The protease and antiprotease imbalance of MMPs and TIMPs are extensively studied in diseases but recent discoveries suggest that TIMPs, specifically, TIMP2 could play other roles in aging and inflammation processes. |
| format | Article |
| id | doaj-art-365353ebbc124b9c93c29335cd73411b |
| institution | Kabale University |
| issn | 2090-1844 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-365353ebbc124b9c93c29335cd73411b2025-02-03T05:57:38ZengWileyPulmonary Medicine2090-18442022-01-01202210.1155/2022/3632764The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the LungsLouis Costanzo0Brian Soto1Richard Meier2Patrick Geraghty3Department of MedicineDepartment of MedicineDepartment of MedicineDepartment of MedicineTissue inhibitors of matrix metalloproteinases (TIMP) are a family of four endogenous proteins that primarily function to inhibit the activities of proteases such as the matrix metalloproteinases (MMP). Altered MMP/TIMP ratios are frequently observed in several human diseases. During aging and disease progression, the extracellular matrix (ECM) undergoes structural changes in which elastin and collagens serve an essential role. MMPs and TIMPs significantly influence the ECM. Classically, elevated levels of TIMPs are suggested to result in ECM accumulation leading to fibrosis, whereas loss of TIMP responses leads to enhanced matrix proteolysis. Here, we outline the known roles of the most abundant TIMP, TIMP2, in pulmonary diseases but also discuss future perspectives in TIMP2 research that could impact the lungs. TIMP2 directly inhibits MMPs, in particular MMP2, but TIMP2 is also required for the activation of MMP2 through its interaction with MMP14. The protease and antiprotease imbalance of MMPs and TIMPs are extensively studied in diseases but recent discoveries suggest that TIMPs, specifically, TIMP2 could play other roles in aging and inflammation processes.http://dx.doi.org/10.1155/2022/3632764 |
| spellingShingle | Louis Costanzo Brian Soto Richard Meier Patrick Geraghty The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs Pulmonary Medicine |
| title | The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs |
| title_full | The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs |
| title_fullStr | The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs |
| title_full_unstemmed | The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs |
| title_short | The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs |
| title_sort | biology and function of tissue inhibitor of metalloproteinase 2 in the lungs |
| url | http://dx.doi.org/10.1155/2022/3632764 |
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