Inhibition of BRD4 attenuated IFNγ-induced apoptosis in colorectal cancer organoids

Inhibition of BRD4 attenuated IFNγ-induced apoptosis in colorectal cancer organoids

Abstract Background This study aimed to analyze the functional role of Brd4 in colorectal cancer (CRC) organoids. Brd4 was identified as a CRC-related gene by our previous Sleeping Beauty mutagenesis transposon screening in mice. Brd4 is a transcriptional regulator that recognizes acetylated histone...

Full description

Saved in:
Bibliographic Details
Main Authors: Akimi Yonezawa, Kana Shimomura, Koji Okamoto, Haruna Takeda
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Cancer
Subjects:
Organoid
Colorectal cancer
Brd4
Apoptosis
JQ1
IFNγ
Online Access:https://doi.org/10.1186/s12885-025-13544-y
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items