A Role for PPARγ in the Regulation of Cytokines in Immune Cells and Cancer
Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor and a member of the nuclear receptor superfamily. PPARγ and its ligands appear to serve diverse biological functions. In addition to the well-studied effects of PPARγ on metabolism and cellular differenti...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2008-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2008/961753 |
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| _version_ | 1832555979450875904 |
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| author | Xiao Yi Yang Li Hua Wang William L. Farrar |
| author_facet | Xiao Yi Yang Li Hua Wang William L. Farrar |
| author_sort | Xiao Yi Yang |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor and a member of the nuclear receptor superfamily. PPARγ and its ligands appear to serve diverse biological functions. In addition to the well-studied effects of PPARγ on metabolism and cellular differentiation, abundant evidence suggests that PPARγ is an important regulator of the immune system and cancers. Since cytokines are not only key modulators of inflammation with pro- and anti-inflammatory functions but they also can either stimulate or inhibit tumor growth and progression, this review summarizes the role for PPARγ in the regulation of cytokine production and cytokine-mediated signal transduction pathways in immune cells and cancer. |
| format | Article |
| id | doaj-art-359395b0c99d4fe19d96bcd590b08e98 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-359395b0c99d4fe19d96bcd590b08e982025-02-03T05:46:33ZengWileyPPAR Research1687-47571687-47652008-01-01200810.1155/2008/961753961753A Role for PPARγ in the Regulation of Cytokines in Immune Cells and CancerXiao Yi Yang0Li Hua Wang1William L. Farrar2Basic Research Program, SAIC-Frederick, National Cancer Institute-Frederick, Frederick, MD 21702, USABasic Research Program, SAIC-Frederick, National Cancer Institute-Frederick, Frederick, MD 21702, USACancer Stem Cell Section, Laboratory of Cancer Prevention, Division of Basic Sciences, National Cancer Institute-Frederick, Frederick, MD 21702, USAPeroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor and a member of the nuclear receptor superfamily. PPARγ and its ligands appear to serve diverse biological functions. In addition to the well-studied effects of PPARγ on metabolism and cellular differentiation, abundant evidence suggests that PPARγ is an important regulator of the immune system and cancers. Since cytokines are not only key modulators of inflammation with pro- and anti-inflammatory functions but they also can either stimulate or inhibit tumor growth and progression, this review summarizes the role for PPARγ in the regulation of cytokine production and cytokine-mediated signal transduction pathways in immune cells and cancer.http://dx.doi.org/10.1155/2008/961753 |
| spellingShingle | Xiao Yi Yang Li Hua Wang William L. Farrar A Role for PPARγ in the Regulation of Cytokines in Immune Cells and Cancer PPAR Research |
| title | A Role for PPARγ in the Regulation of Cytokines in Immune Cells and Cancer |
| title_full | A Role for PPARγ in the Regulation of Cytokines in Immune Cells and Cancer |
| title_fullStr | A Role for PPARγ in the Regulation of Cytokines in Immune Cells and Cancer |
| title_full_unstemmed | A Role for PPARγ in the Regulation of Cytokines in Immune Cells and Cancer |
| title_short | A Role for PPARγ in the Regulation of Cytokines in Immune Cells and Cancer |
| title_sort | role for pparγ in the regulation of cytokines in immune cells and cancer |
| url | http://dx.doi.org/10.1155/2008/961753 |
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