Applications of Amniotic Membrane and Fluid in Stem Cell Biology and Regenerative Medicine
The amniotic membrane (AM) and amniotic fluid (AF) have a long history of use in surgical and prenatal diagnostic applications, respectively. In addition, the discovery of cell populations in AM and AF which are widely accessible, nontumorigenic and capable of differentiating into a variety of cell...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2012/721538 |
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| _version_ | 1832555413510291456 |
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| author | Kerry Rennie Andrée Gruslin Markus Hengstschläger Duanqing Pei Jinglei Cai Toshio Nikaido Mahmud Bani-Yaghoub |
| author_facet | Kerry Rennie Andrée Gruslin Markus Hengstschläger Duanqing Pei Jinglei Cai Toshio Nikaido Mahmud Bani-Yaghoub |
| author_sort | Kerry Rennie |
| collection | DOAJ |
| description | The amniotic membrane (AM) and amniotic fluid (AF) have a long history of use in surgical and prenatal diagnostic applications, respectively. In addition, the discovery of cell populations in AM and AF which are widely accessible, nontumorigenic and capable of differentiating into a variety of cell types has stimulated a flurry of research aimed at characterizing the cells and evaluating their potential utility in regenerative medicine. While a major focus of research has been the use of amniotic membrane and fluid in tissue engineering and cell replacement, AM- and AF-derived cells may also have capabilities in protecting and stimulating the repair of injured tissues via paracrine actions, and acting as vectors for biodelivery of exogenous factors to treat injury and diseases. Much progress has been made since the discovery of AM and AF cells with stem cell characteristics nearly a decade ago, but there remain a number of problematic issues stemming from the inherent heterogeneity of these cells as well as inconsistencies in isolation and culturing methods which must be addressed to advance the field towards the development of cell-based therapies. Here, we provide an overview of the recent progress and future perspectives in the use of AM- and AF-derived cells for therapeutic applications. |
| format | Article |
| id | doaj-art-3579ce2ce3d74e4e95f74289c8c3d654 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-3579ce2ce3d74e4e95f74289c8c3d6542025-02-03T05:48:16ZengWileyStem Cells International1687-966X1687-96782012-01-01201210.1155/2012/721538721538Applications of Amniotic Membrane and Fluid in Stem Cell Biology and Regenerative MedicineKerry Rennie0Andrée Gruslin1Markus Hengstschläger2Duanqing Pei3Jinglei Cai4Toshio Nikaido5Mahmud Bani-Yaghoub6Neurogenesis and Brain Repair, National Research Council-Institute for Biological Sciences, Bldg. M-54, Ottawa, ON, K1A 0R6, CanadaDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, KIH 845, CanadaInstitute of Medical Genetics, Medical University of Vienna, Währinger Straße 10, 1090, Vienna, AustriaKey Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Chinese Academy of Sciences, 190 Kai Yuan Avenue, Science Park, Guangzhou 510530, ChinaKey Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Chinese Academy of Sciences, 190 Kai Yuan Avenue, Science Park, Guangzhou 510530, ChinaDepartment of Regenerative Medicine, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930-0194, JapanNeurogenesis and Brain Repair, National Research Council-Institute for Biological Sciences, Bldg. M-54, Ottawa, ON, K1A 0R6, CanadaThe amniotic membrane (AM) and amniotic fluid (AF) have a long history of use in surgical and prenatal diagnostic applications, respectively. In addition, the discovery of cell populations in AM and AF which are widely accessible, nontumorigenic and capable of differentiating into a variety of cell types has stimulated a flurry of research aimed at characterizing the cells and evaluating their potential utility in regenerative medicine. While a major focus of research has been the use of amniotic membrane and fluid in tissue engineering and cell replacement, AM- and AF-derived cells may also have capabilities in protecting and stimulating the repair of injured tissues via paracrine actions, and acting as vectors for biodelivery of exogenous factors to treat injury and diseases. Much progress has been made since the discovery of AM and AF cells with stem cell characteristics nearly a decade ago, but there remain a number of problematic issues stemming from the inherent heterogeneity of these cells as well as inconsistencies in isolation and culturing methods which must be addressed to advance the field towards the development of cell-based therapies. Here, we provide an overview of the recent progress and future perspectives in the use of AM- and AF-derived cells for therapeutic applications.http://dx.doi.org/10.1155/2012/721538 |
| spellingShingle | Kerry Rennie Andrée Gruslin Markus Hengstschläger Duanqing Pei Jinglei Cai Toshio Nikaido Mahmud Bani-Yaghoub Applications of Amniotic Membrane and Fluid in Stem Cell Biology and Regenerative Medicine Stem Cells International |
| title | Applications of Amniotic Membrane and Fluid in Stem Cell Biology and Regenerative Medicine |
| title_full | Applications of Amniotic Membrane and Fluid in Stem Cell Biology and Regenerative Medicine |
| title_fullStr | Applications of Amniotic Membrane and Fluid in Stem Cell Biology and Regenerative Medicine |
| title_full_unstemmed | Applications of Amniotic Membrane and Fluid in Stem Cell Biology and Regenerative Medicine |
| title_short | Applications of Amniotic Membrane and Fluid in Stem Cell Biology and Regenerative Medicine |
| title_sort | applications of amniotic membrane and fluid in stem cell biology and regenerative medicine |
| url | http://dx.doi.org/10.1155/2012/721538 |
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