Mesenchymal stromal cells highly expressing Sca-1 promote breast cancer lung metastasis through recruiting myeloid cells

Abstract Mesenchymal stem/stromal cells (MSCs) are integral components of the tumor microenvironment and critical for the colonization of disseminated cancer cells; specifically, stem cell antigen (Sca-1) is recognized as a surface marker of MSCs. In this study, we found that MSCs highly expressing...

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Main Authors: Lijuan Cao, Yanan Li, Minghui Ou, Artem Smirnov, Rui Liu, Tingting Wang, Xiao Su, Peishan Li, Mancini Mara, Eleonora Candi, Zhiyuan Zheng, Gerry Melino, Changshun Shao, Yufang Shi
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07845-0
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