TRIM25 and ZAP target the Ebola virus ribonucleoprotein complex to mediate interferon-induced restriction.

TRIM25 and ZAP target the Ebola virus ribonucleoprotein complex to mediate interferon-induced restriction.

Ebola virus (EBOV) causes highly pathogenic disease in primates. Through screening a library of human interferon-stimulated genes (ISGs), we identified TRIM25 as a potent inhibitor of EBOV transcription-and-replication-competent virus-like particle (trVLP) propagation. TRIM25 overexpression inhibite...

Full description

Saved in:
Bibliographic Details
Main Authors: Rui Pedro Galão, Harry Wilson, Kristina L Schierhorn, Franka Debeljak, Bianca S Bodmer, Daniel Goldhill, Thomas Hoenen, Sam J Wilson, Chad M Swanson, Stuart J D Neil
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-05-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1010530
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1371/journal.ppat.1010530

Similar Items