A Review of Integration Strategies to Support Gene Regulatory Network Construction
Gene regulatory network (GRN) construction is a central task of systems biology. Integration of different data sources to infer and construct GRNs is an important consideration for the success of this effort. In this paper, we will discuss distinctive strategies of data integration for GRN construct...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/435257 |
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| _version_ | 1832556544663748608 |
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| author | Hailin Chen Vincent VanBuren |
| author_facet | Hailin Chen Vincent VanBuren |
| author_sort | Hailin Chen |
| collection | DOAJ |
| description | Gene regulatory network (GRN) construction is a central task of systems biology. Integration of different data sources to infer and construct GRNs is an important consideration for the success of this effort. In this paper, we will discuss distinctive strategies of data integration for GRN construction. Basically, the process of integration of different data sources is divided into two phases: the first phase is collection of the required data and the second phase is data processing with advanced algorithms to infer the GRNs. In this paper these two phases are called “structural integration” and “analytic integration,” respectively. Compared with the nonintegration strategies, the integration strategies perform quite well and have better agreement with the experimental evidence. |
| format | Article |
| id | doaj-art-34811d4264fe4cae89e81f82940e0d8a |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-34811d4264fe4cae89e81f82940e0d8a2025-02-03T05:45:01ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/435257435257A Review of Integration Strategies to Support Gene Regulatory Network ConstructionHailin Chen0Vincent VanBuren1Department of Medical Physiology, Texas A&M HSC College of Medicine, Temple, TX 76504, USADepartment of Medical Physiology, Texas A&M HSC College of Medicine, Temple, TX 76504, USAGene regulatory network (GRN) construction is a central task of systems biology. Integration of different data sources to infer and construct GRNs is an important consideration for the success of this effort. In this paper, we will discuss distinctive strategies of data integration for GRN construction. Basically, the process of integration of different data sources is divided into two phases: the first phase is collection of the required data and the second phase is data processing with advanced algorithms to infer the GRNs. In this paper these two phases are called “structural integration” and “analytic integration,” respectively. Compared with the nonintegration strategies, the integration strategies perform quite well and have better agreement with the experimental evidence.http://dx.doi.org/10.1100/2012/435257 |
| spellingShingle | Hailin Chen Vincent VanBuren A Review of Integration Strategies to Support Gene Regulatory Network Construction The Scientific World Journal |
| title | A Review of Integration Strategies to Support Gene Regulatory Network Construction |
| title_full | A Review of Integration Strategies to Support Gene Regulatory Network Construction |
| title_fullStr | A Review of Integration Strategies to Support Gene Regulatory Network Construction |
| title_full_unstemmed | A Review of Integration Strategies to Support Gene Regulatory Network Construction |
| title_short | A Review of Integration Strategies to Support Gene Regulatory Network Construction |
| title_sort | review of integration strategies to support gene regulatory network construction |
| url | http://dx.doi.org/10.1100/2012/435257 |
| work_keys_str_mv | AT hailinchen areviewofintegrationstrategiestosupportgeneregulatorynetworkconstruction AT vincentvanburen areviewofintegrationstrategiestosupportgeneregulatorynetworkconstruction AT hailinchen reviewofintegrationstrategiestosupportgeneregulatorynetworkconstruction AT vincentvanburen reviewofintegrationstrategiestosupportgeneregulatorynetworkconstruction |