Circadian rhythm disruption by PARP inhibitors correlates with treatment toxicity in patients with ovarian cancer and is a predictor of side effectsResearch in context

Circadian rhythm disruption by PARP inhibitors correlates with treatment toxicity in patients with ovarian cancer and is a predictor of side effectsResearch in context

Summary: Background: Ovarian cancer is among the most lethal malignancies in women. The advent of PARP inhibitors (PARPi) has improved outcomes. However, treatment-related toxicity remains a critical challenge, impacting patient quality of life and treatment adherence. Methods: In a circadian sub-s...

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Main Authors: Deeksha Malhan, Janina Hesse, Nina Nelson, Kay Stankov, Jessica Nguyen, Ouda Aboumanify, Josefin Garmshausen, Gunther Rogmans, Bastian Czogalla, Jens Gerber, Martin Koch, Tomáš Kupec, Oliver Tomé, Ralf Witteler, Mustafa Deryal, Michael Eichbaum, Jalid Sehouli, Elena Ioana Braicu, Angela Relógio
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:EBioMedicine
Subjects:
Circadian rhythms
Ovarian cancer
Circadian profiles
Chronotherapy
Adverse events
Mathematical modelling
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425002087
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