Ziziphus spina-christi alleviates paracetamol-induced hepatorenal toxicity in rats through in vivo and computational approaches

Ziziphus spina-christi alleviates paracetamol-induced hepatorenal toxicity in rats through in vivo and computational approaches

Abstract Paracetamol (PCM) overdose is a leading cause of drug-induced liver and kidney injury, necessitating effective therapeutic strategies. This study aimed to evaluate the protective effects of Ziziphus spina-christi (ZSC), a traditional medicinal plant with documented antioxidant and protectiv...

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Main Authors: Ehsan Kh. M. Khedre, Amany M. M. Hegab, Amira A. El-Mahis, Amina A. S. Abdel Rahman, Sherien H. B. Elwakeel, Ali S. Abdelhameed, Vittorio Calabrese, Ursula M. Jacob, Eman S. G. Hassan
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Ziziphus spina-christi
NF-κB/TNF-α signaling pathway
Bax/Bcl-2/caspase-3 signaling pathway
ERK/JNK/p38 MAPK signaling pathway
Molecular docking
Online Access:https://doi.org/10.1038/s41598-025-14454-6
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https://doi.org/10.1038/s41598-025-14454-6

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