Influence of probiotics and deoxycholate on azathioprine transport in the PAMPA model: insights into pharmacomicrobiomics and interindividual variability in drug response

Influence of probiotics and deoxycholate on azathioprine transport in the PAMPA model: insights into pharmacomicrobiomics and interindividual variability in drug response

IntroductionInterindividual variability in drug response presents a major clinical challenge, necessitating a deeper understanding of contributing factors. While the role of gut microbiota, probiotics and bile acids in modulating drug metabolism, absorption, and bioavailability is increasingly recog...

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Main Authors: Maja Đanić, Nebojša Pavlović, Natalija Dedić, Dragana Zaklan, Slavica Lazarević, Bojan Stanimirov, Momir Mikov
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
drug transport
probiotics
permeability
intestinal microbiota
azathioprine
inflammatory bowel disease
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1608110/full
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