Circulating Extracellular Vesicles as Putative Mediators of Cardiovascular Disease in Paediatric Chronic Kidney Disease

Circulating Extracellular Vesicles as Putative Mediators of Cardiovascular Disease in Paediatric Chronic Kidney Disease

ABSTRACT Cardiovascular disease (CVD) is the leading cause of mortality in chronic kidney disease (CKD). However, the pathogenesis of CVD in CKD remains incompletely understood. Endothelial extracellular vesicles (EC‐EVs) have previously been associated with CVD. We hypothesized that CKD alters EV r...

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Main Authors: Felix Behrens, Johannes Holle, Chia‐Yu Chen, Laura F. Ginsbach, Benjamin C. Krause, Ulrike Bruning, Fabian L. Kriegel, Toralf Kaiser, István A. Szijártó, Harithaa Anandakumar, Katrin Lehmann, Fabian Schumacher, Pawel Durek, Frederik F. Heinrich, Dörte Lodka, Carina Hoffmann, André A. Borchardt, Lisa Peters, Laura Michalick, Uwe Querfeld, Philip Bufler, Andreas Luch, Burkhard Kleuser, Jennifer A. Kirwan, Sofia K. Forslund, Julia Thumfahrt, Dominik Müller, Nicola Wilck, Mir‐Farzin Mashreghi, Ulrike Löber, Hendrik Bartolomaeus, Wolfgang M. Kuebler, Szandor Simmons
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Journal of Extracellular Vesicles
Subjects:
chronic kidney disease
cardiovascular disease
microRNAs
angiogenesis
uremic toxins
shear stress
Online Access:https://doi.org/10.1002/jev2.70062
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https://doi.org/10.1002/jev2.70062

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