Therapeutic reduction of neurocan in murine intracerebral hemorrhage lesions promotes oligodendrogenesis and functional recovery

Therapeutic reduction of neurocan in murine intracerebral hemorrhage lesions promotes oligodendrogenesis and functional recovery

Abstract Background Intracerebral hemorrhage (ICH) causes prominent deposition of extracellular matrix molecules, particularly the chondroitin sulphate proteoglycan (CSPG) member neurocan. In tissue culture, neurocan impedes the properties of oligodendrocytes. Whether therapeutic reduction of neuroc...

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Bibliographic Details
Main Authors: Hongmin Li, Samira Ghorbani, Olayinka Oladosu, Ping Zhang, Frank Visser, Jeff Dunn, Yunyan Zhang, Chang-Chun Ling, V. Wee Yong, Mengzhou Xue
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Neuroinflammation
Subjects:
Extracellular matrix
Neurocan
Chondroitin sulphate proteoglycans
Oligodendrogenesis
Functional recovery
Intracerebral hemorrhage
Online Access:https://doi.org/10.1186/s12974-024-03331-0
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https://doi.org/10.1186/s12974-024-03331-0

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