Fructosamine measurement for diabetes mellitus diagnosis and monitoring: a systematic review and meta-analysis protocol
Introduction Fructosamine is a marker of glucose control reflecting the average glycaemic level over the preceding 2–3 weeks. Fructosamine has not gained as much popularity as glycated haemoglobin (HbA1c) for diabetes mellitus (DM) control monitoring, and the related underlying reasons remain unclea...
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| Format: | Article |
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BMJ Publishing Group
2015-05-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/5/5/e007689.full |
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| author | Andre Pascal Kengne Eugene Sobngwi Jean Jacques N Noubiap Jobert Richie N Nansseu Joël Fokom-Domgue Eric V Balti |
| author_facet | Andre Pascal Kengne Eugene Sobngwi Jean Jacques N Noubiap Jobert Richie N Nansseu Joël Fokom-Domgue Eric V Balti |
| author_sort | Andre Pascal Kengne |
| collection | DOAJ |
| description | Introduction Fructosamine is a marker of glucose control reflecting the average glycaemic level over the preceding 2–3 weeks. Fructosamine has not gained as much popularity as glycated haemoglobin (HbA1c) for diabetes mellitus (DM) control monitoring, and the related underlying reasons remain unclear. We aim to search for and summarise available evidence on the accuracy of fructosamine measurements to diagnose and monitor DM.Methods and analysis This systematic review will include randomised control trials, controlled before-and-after studies, time series designs, cohort studies, case–control studies and cross-sectional surveys reporting the diagnosis and/or monitoring of DM (type 1 DM, type 2 DM and gestational DM) with fructosamine compared with other measures of glycaemia (fasting glucose, oral glucose tolerance test, random glucose, HbA1c), without any language restriction. We will perform electronic searches in PubMed, Scopus and other databases, supplemented with manual searches. Articles published from 1 January 1980 to 30 June 2015 will be eligible for inclusion in this review. Two authors will independently screen, select studies, extract data and assess the risk of bias with discrepancies resolved by consensus. We will assess clinical heterogeneity by examining the types of interventions and outcomes in each study, and pool studies judged to be clinically homogeneous. We will also assess statistical heterogeneity using the χ2 test of homogeneity and quantify it using the I2 statistic. Absolute accuracy measures (sensitivity, specificity) will be pooled in a bivariate random-effects model, allowing for intersetting variability. Negative and positive predictive values will be computed for fructosamine, compared with another measure of glycaemia from the pooled estimates of sensitivity and specificity, using Bayes’ theorem.Ethics and dissemination This systematic review will use data from published studies and does not require ethics approval. Findings will be published in a peer-reviewed journal and presented at scientific conferences.Trial registration number PROSPERO (ID=CRD42015015930). |
| format | Article |
| id | doaj-art-33e90aac98d54e04b1702d92960ac964 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2015-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-33e90aac98d54e04b1702d92960ac9642025-02-06T15:45:11ZengBMJ Publishing GroupBMJ Open2044-60552015-05-015510.1136/bmjopen-2015-007689Fructosamine measurement for diabetes mellitus diagnosis and monitoring: a systematic review and meta-analysis protocolAndre Pascal Kengne0Eugene Sobngwi1Jean Jacques N Noubiap2Jobert Richie N Nansseu3Joël Fokom-Domgue4Eric V Balti5Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, Western Cape, South AfricaNational Obesity Centre and Endocrinology and Metabolic Diseases Unit, Yaounde Central Hospital, Yaounde, CameroonDepartment of Medicine, Groote Schuur Hospital and University of Cape Town, Cape Town, South AfricaSickle Cell Disease Unit, Mother and Child Centre, Chantal Biya Foundation, Yaoundé, Centre Region, Cameroonresearch fellowNational Obesity Centre, Yaoundé Central Hospital, Yaoundé, Centre Region, CameroonIntroduction Fructosamine is a marker of glucose control reflecting the average glycaemic level over the preceding 2–3 weeks. Fructosamine has not gained as much popularity as glycated haemoglobin (HbA1c) for diabetes mellitus (DM) control monitoring, and the related underlying reasons remain unclear. We aim to search for and summarise available evidence on the accuracy of fructosamine measurements to diagnose and monitor DM.Methods and analysis This systematic review will include randomised control trials, controlled before-and-after studies, time series designs, cohort studies, case–control studies and cross-sectional surveys reporting the diagnosis and/or monitoring of DM (type 1 DM, type 2 DM and gestational DM) with fructosamine compared with other measures of glycaemia (fasting glucose, oral glucose tolerance test, random glucose, HbA1c), without any language restriction. We will perform electronic searches in PubMed, Scopus and other databases, supplemented with manual searches. Articles published from 1 January 1980 to 30 June 2015 will be eligible for inclusion in this review. Two authors will independently screen, select studies, extract data and assess the risk of bias with discrepancies resolved by consensus. We will assess clinical heterogeneity by examining the types of interventions and outcomes in each study, and pool studies judged to be clinically homogeneous. We will also assess statistical heterogeneity using the χ2 test of homogeneity and quantify it using the I2 statistic. Absolute accuracy measures (sensitivity, specificity) will be pooled in a bivariate random-effects model, allowing for intersetting variability. Negative and positive predictive values will be computed for fructosamine, compared with another measure of glycaemia from the pooled estimates of sensitivity and specificity, using Bayes’ theorem.Ethics and dissemination This systematic review will use data from published studies and does not require ethics approval. Findings will be published in a peer-reviewed journal and presented at scientific conferences.Trial registration number PROSPERO (ID=CRD42015015930).https://bmjopen.bmj.com/content/5/5/e007689.full |
| spellingShingle | Andre Pascal Kengne Eugene Sobngwi Jean Jacques N Noubiap Jobert Richie N Nansseu Joël Fokom-Domgue Eric V Balti Fructosamine measurement for diabetes mellitus diagnosis and monitoring: a systematic review and meta-analysis protocol BMJ Open |
| title | Fructosamine measurement for diabetes mellitus diagnosis and monitoring: a systematic review and meta-analysis protocol |
| title_full | Fructosamine measurement for diabetes mellitus diagnosis and monitoring: a systematic review and meta-analysis protocol |
| title_fullStr | Fructosamine measurement for diabetes mellitus diagnosis and monitoring: a systematic review and meta-analysis protocol |
| title_full_unstemmed | Fructosamine measurement for diabetes mellitus diagnosis and monitoring: a systematic review and meta-analysis protocol |
| title_short | Fructosamine measurement for diabetes mellitus diagnosis and monitoring: a systematic review and meta-analysis protocol |
| title_sort | fructosamine measurement for diabetes mellitus diagnosis and monitoring a systematic review and meta analysis protocol |
| url | https://bmjopen.bmj.com/content/5/5/e007689.full |
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