PIM2 inhibition promotes MCL1 dependency in plasma cells involving integrated stress response-driven NOXA expression

PIM2 inhibition promotes MCL1 dependency in plasma cells involving integrated stress response-driven NOXA expression

Abstract Our study explores the complex dynamics of the integrated stress response (ISR) axis, highlighting PIM2 kinase’s critical role and its interaction with the BCL2 protein family, uncovering key mechanisms of cell survival and tumor progression. Elevated PIM2 expression, a marker of various ca...

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Main Authors: Marion Haas, Sabrina Cherfa, Léa Nguyen, Maxence Bourgoin, Gersende Caron, Elise Dessauge, Tony Marchand, Laurent Delpy, Patrick Auberger, Jérôme Moreaux, Arnaud Jacquel, Thierry Fest
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55572-5
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https://doi.org/10.1038/s41467-024-55572-5

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