Clinical characteristics and prognosis of patients treated as invasive pulmonary aspergillosis outside of severe immunosuppression
Abstract This study aimed to identify clinical characteristics and develop a prognostic model for non-neutropenic patients with invasive pulmonary aspergillosis (IPA). A retrospective analysis of 151 IPA patients was conducted, with patients categorized into survival (n = 117) and death (n = 34) gro...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-87605-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832571712974094336 |
|---|---|
| author | Furui Liu Wenling Chen Honglei Qi Yonghong Yang Ying Yang Zhaojun Wang Jinyuan Zhu |
| author_facet | Furui Liu Wenling Chen Honglei Qi Yonghong Yang Ying Yang Zhaojun Wang Jinyuan Zhu |
| author_sort | Furui Liu |
| collection | DOAJ |
| description | Abstract This study aimed to identify clinical characteristics and develop a prognostic model for non-neutropenic patients with invasive pulmonary aspergillosis (IPA). A retrospective analysis of 151 IPA patients was conducted, with patients categorized into survival (n = 117) and death (n = 34) groups. Clinical data, including demographics, laboratory tests, and imaging, were collected. Multivariate Cox regression analysis identified glucocorticoid use (odds ratio [OR] = 30.223, 95% confidence interval [CI]: 2.676–341.306), intensive care unit admission (OR = 0.133, 95% CI: 0.023–0.758), and the arterial oxygen partial pressure/fractional inspired oxygen ratio (OR = 0.994, 95% CI: 0.990–0.999) as significant predictors of 28-day mortality. A prognostic model was developed based on these factors, showing high predictive accuracy (receiver operating characteristic curve area of 0.918). The model’s clinical applicability was validated through calibration curves, bootstrap internal validation, decision curve analysis, and clinical impact curves. Kaplan–Meier analysis further confirmed its utility, indicating a worse prognosis for high-risk patients within 50 days and the highest survival rate at 14 days. This novel model offers valuable insights for predicting survival in non-neutropenic IPA patients. |
| format | Article |
| id | doaj-art-33d42d34409b4ef8827a5a0fcf9f4a0d |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-33d42d34409b4ef8827a5a0fcf9f4a0d2025-02-02T12:20:41ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-025-87605-4Clinical characteristics and prognosis of patients treated as invasive pulmonary aspergillosis outside of severe immunosuppressionFurui Liu0Wenling Chen1Honglei Qi2Yonghong Yang3Ying Yang4Zhaojun Wang5Jinyuan Zhu6The First School of Clinical Medicine, Ningxia Medical UniversityThe First School of Clinical Medicine, Ningxia Medical UniversityThe First School of Clinical Medicine, Ningxia Medical UniversityThe First School of Clinical Medicine, Ningxia Medical UniversityThe First School of Clinical Medicine, Ningxia Medical UniversityDepartment of Critical Care Medicine, General Hospital of Ningxia Medical UniversityDepartment of Critical Care Medicine, General Hospital of Ningxia Medical UniversityAbstract This study aimed to identify clinical characteristics and develop a prognostic model for non-neutropenic patients with invasive pulmonary aspergillosis (IPA). A retrospective analysis of 151 IPA patients was conducted, with patients categorized into survival (n = 117) and death (n = 34) groups. Clinical data, including demographics, laboratory tests, and imaging, were collected. Multivariate Cox regression analysis identified glucocorticoid use (odds ratio [OR] = 30.223, 95% confidence interval [CI]: 2.676–341.306), intensive care unit admission (OR = 0.133, 95% CI: 0.023–0.758), and the arterial oxygen partial pressure/fractional inspired oxygen ratio (OR = 0.994, 95% CI: 0.990–0.999) as significant predictors of 28-day mortality. A prognostic model was developed based on these factors, showing high predictive accuracy (receiver operating characteristic curve area of 0.918). The model’s clinical applicability was validated through calibration curves, bootstrap internal validation, decision curve analysis, and clinical impact curves. Kaplan–Meier analysis further confirmed its utility, indicating a worse prognosis for high-risk patients within 50 days and the highest survival rate at 14 days. This novel model offers valuable insights for predicting survival in non-neutropenic IPA patients.https://doi.org/10.1038/s41598-025-87605-4Non-neutropeniaInvasive pulmonary aspergillusMortalityPrognosis |
| spellingShingle | Furui Liu Wenling Chen Honglei Qi Yonghong Yang Ying Yang Zhaojun Wang Jinyuan Zhu Clinical characteristics and prognosis of patients treated as invasive pulmonary aspergillosis outside of severe immunosuppression Scientific Reports Non-neutropenia Invasive pulmonary aspergillus Mortality Prognosis |
| title | Clinical characteristics and prognosis of patients treated as invasive pulmonary aspergillosis outside of severe immunosuppression |
| title_full | Clinical characteristics and prognosis of patients treated as invasive pulmonary aspergillosis outside of severe immunosuppression |
| title_fullStr | Clinical characteristics and prognosis of patients treated as invasive pulmonary aspergillosis outside of severe immunosuppression |
| title_full_unstemmed | Clinical characteristics and prognosis of patients treated as invasive pulmonary aspergillosis outside of severe immunosuppression |
| title_short | Clinical characteristics and prognosis of patients treated as invasive pulmonary aspergillosis outside of severe immunosuppression |
| title_sort | clinical characteristics and prognosis of patients treated as invasive pulmonary aspergillosis outside of severe immunosuppression |
| topic | Non-neutropenia Invasive pulmonary aspergillus Mortality Prognosis |
| url | https://doi.org/10.1038/s41598-025-87605-4 |
| work_keys_str_mv | AT furuiliu clinicalcharacteristicsandprognosisofpatientstreatedasinvasivepulmonaryaspergillosisoutsideofsevereimmunosuppression AT wenlingchen clinicalcharacteristicsandprognosisofpatientstreatedasinvasivepulmonaryaspergillosisoutsideofsevereimmunosuppression AT hongleiqi clinicalcharacteristicsandprognosisofpatientstreatedasinvasivepulmonaryaspergillosisoutsideofsevereimmunosuppression AT yonghongyang clinicalcharacteristicsandprognosisofpatientstreatedasinvasivepulmonaryaspergillosisoutsideofsevereimmunosuppression AT yingyang clinicalcharacteristicsandprognosisofpatientstreatedasinvasivepulmonaryaspergillosisoutsideofsevereimmunosuppression AT zhaojunwang clinicalcharacteristicsandprognosisofpatientstreatedasinvasivepulmonaryaspergillosisoutsideofsevereimmunosuppression AT jinyuanzhu clinicalcharacteristicsandprognosisofpatientstreatedasinvasivepulmonaryaspergillosisoutsideofsevereimmunosuppression |